RNA-Dependent Intergenerational Inheritance of Enhanced Synaptic Plasticity after Environmental Enrichment

被引：102

作者：

Benito, Eva ^{[1
]}

Kerimoglu, Cemil ^{[1
]}

Ramachandran, Binu ^{[2
]}

Pena-Centeno, Tonatiuh ^{[1
,3
]}

Jain, Gaurav ^{[1
,3
]}

Stilling, Roman Manuel ^{[1
]}

Islam, Md Rezaul ^{[1
]}

Capece, Vincenzo ^{[1
,3
]}

Zhou, Qihui ^{[4
]}

Edbauer, Dieter ^{[4
]}

Dean, Camin ^{[2
]}

Fischer, Andre ^{[1
,5
]}

机构：

[1] German Ctr Neurodegenerat Dis DZNE Gottingen, Dept Epigenet & Syst Med Neurodegenerat Dis, von Siebold Str 3A, D-37075 Gottingen, Germany

[2] European Neurosci Inst, Transsynapt Signaling Grp, Grisebachstr 5, D-37077 Gottingen, Germany

[3] German Ctr Neurodegenerat Dis DZNE Gottingen, Bioinformat Unit, von Siebold Str 3A, D-37075 Gottingen, Germany

[4] German Ctr Neurodegenerat Dis DZNE, Feodor Lynen Str 17, D-81377 Munich, Germany

[5] Univ Med Ctr Gottingen, Dept Psychiat & Psychotherapy, von Siebold Str 5, D-37075 Gottingen, Germany

来源：

CELL REPORTS | 2018年 / 23卷 / 02期

基金：

欧洲研究理事会;

关键词：

MEMORY FORMATION; PATERNAL STRESS; BRAIN; DISORDERS; MICE; DISEASE; TRAUMA; MODELS; ALTERS; MOUSE;

D O I：

10.1016/j.celrep.2018.03.059

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Physical exercise in combination with cognitive training is known to enhance synaptic plasticity, learning, and memory and lower the risk for various complex diseases including Alzheimer's disease. Here, we show that exposure of adult male mice to an environmental enrichment paradigm leads to enhancement of synaptic plasticity and cognition also in the next generation. We show that this effect is mediated through sperm RNA and especially miRs 212/132. In conclusion, our study reports intergenerational inheritance of an acquired cognitive benefit and points to specific miRs as candidates mechanistically involved in this type of transmission.

引用

页码：546 / 554

页数：9

共 36 条

[1] Transgenerational Rescue of a Genetic Defect in Long-Term Potentiation and Memory Formation by Juvenile Enrichment [J].

Arai, Junko A. ;

Li, Shaomin ;

Hartley, Dean M. ;

Feig, Larry A. .

JOURNAL OF NEUROSCIENCE, 2009, 29 (05) :1496-1502

[2] Epigenetic and transgenerational reprogramming of brain development [J].

Bale, Tracy L. .

NATURE REVIEWS NEUROSCIENCE, 2015, 16 (06) :332-344

[3] Early Life Programming and Neurodevelopmental Disorders [J].

Bale, Tracy L. ;

Baram, Tallie Z. ;

Brown, Alan S. ;

Goldstein, Jill M. ;

Insel, Thomas R. ;

McCarthy, Margaret M. ;

Nemeroff, Charles B. ;

Reyes, Teresa M. ;

Simerly, Richard B. ;

Susser, Ezra S. ;

Nestler, Eric J. .

BIOLOGICAL PSYCHIATRY, 2010, 68 (04) :314-319

[4] Molecular insights into transgenerational non-genetic inheritance of acquired behaviours [J].

Bohacek, Johannes ;

Mansuy, Isabelle M. .

NATURE REVIEWS GENETICS, 2015, 16 (11) :641-652

[5] Multiple effects of physical activity on molecular and cognitive signs of brain aging: can exercise slow neurodegeneration and delay Alzheimer's disease? [J].

Brown, B. M. ;

Peiffer, J. J. ;

Martins, R. N. .

MOLECULAR PSYCHIATRY, 2013, 18 (08) :864-874

[6] Convergent repression of Foxp2 3′UTR by miR-9 and miR-132 in embryonic mouse neocortex: implications for radial migration of neurons [J].

Clovis, Yoanne M. ;

Enard, Wolfgang ;

Marinaro, Federica ;

Huttner, Wieland B. ;

Tonelli, Davide De Pietri .

DEVELOPMENT, 2012, 139 (18) :3332-3342

[7] Fetal programming of neuropsychiatric disorders [J].

Faa, Gavino ;

Manchia, Mirko ;

Pintus, Roberta ;

Gerosa, Clara ;

Marcialis, Maria Antonietta ;

Fanos, Vassilios .

BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS, 2016, 108 (03) :207-223

[8] Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory [J].

Fischer, A ;

Sananbenesi, F ;

Pang, PT ;

Lu, B ;

Tsai, LH .

NEURON, 2005, 48 (05) :825-838

[9] Recovery of learning and memory is associated with chromatin remodelling [J].

Andre Fischer ;

Farahnaz Sananbenesi ;

Xinyu Wang ;

Matthew Dobbin ;

Li-Huei Tsai .

Nature, 2007, 447 (7141) :178-182

[10] Environmental enrichment as a method to improve cognitive function. What can we learn from animal models? [J].

Fischer, Andre .

NEUROIMAGE, 2016, 131 :42-47

← 1 2 3 4 →