RNA-Dependent Intergenerational Inheritance of Enhanced Synaptic Plasticity after Environmental Enrichment

被引：100

作者：

Benito, Eva ^{[1
]}

Kerimoglu, Cemil ^{[1
]}

Ramachandran, Binu ^{[2
]}

Pena-Centeno, Tonatiuh ^{[1
,3
]}

Jain, Gaurav ^{[1
,3
]}

Stilling, Roman Manuel ^{[1
]}

Islam, Md Rezaul ^{[1
]}

Capece, Vincenzo ^{[1
,3
]}

Zhou, Qihui ^{[4
]}

Edbauer, Dieter ^{[4
]}

Dean, Camin ^{[2
]}

Fischer, Andre ^{[1
,5
]}

机构：

[1] German Ctr Neurodegenerat Dis DZNE Gottingen, Dept Epigenet & Syst Med Neurodegenerat Dis, von Siebold Str 3A, D-37075 Gottingen, Germany

[2] European Neurosci Inst, Transsynapt Signaling Grp, Grisebachstr 5, D-37077 Gottingen, Germany

[3] German Ctr Neurodegenerat Dis DZNE Gottingen, Bioinformat Unit, von Siebold Str 3A, D-37075 Gottingen, Germany

[4] German Ctr Neurodegenerat Dis DZNE, Feodor Lynen Str 17, D-81377 Munich, Germany

[5] Univ Med Ctr Gottingen, Dept Psychiat & Psychotherapy, von Siebold Str 5, D-37075 Gottingen, Germany

来源：

CELL REPORTS | 2018年 / 23卷 / 02期

基金：

欧洲研究理事会;

关键词：

MEMORY FORMATION; PATERNAL STRESS; BRAIN; DISORDERS; MICE; DISEASE; TRAUMA; MODELS; ALTERS; MOUSE;

D O I：

10.1016/j.celrep.2018.03.059

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Physical exercise in combination with cognitive training is known to enhance synaptic plasticity, learning, and memory and lower the risk for various complex diseases including Alzheimer's disease. Here, we show that exposure of adult male mice to an environmental enrichment paradigm leads to enhancement of synaptic plasticity and cognition also in the next generation. We show that this effect is mediated through sperm RNA and especially miRs 212/132. In conclusion, our study reports intergenerational inheritance of an acquired cognitive benefit and points to specific miRs as candidates mechanistically involved in this type of transmission.

引用

页码：546 / 554

页数：9

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