Photoactivation of imatinib-antibody conjugate using low-energy visible light from Ru(II)-polypyridyl cages

被引：25

作者：

Rohrabaugh, Thomas N., Jr. ^{[1
]}

Rohrabaugh, Ashley M. ^{[2
]}

Kodanko, Jeremy J. ^{[3
]}

White, Jessica K. ^{[4
]}

Turro, Claudia ^{[1
]}

机构：

[1] Ohio State Univ, Dept Chem & Biochem, Columbus, OH 43210 USA

[2] Ohio State Univ, Dept Mol Genet, Columbus, OH 43210 USA

[3] Wayne State Univ, Dept Chem, Detroit, MI 48202 USA

[4] Ohio Univ, Dept Chem & Biochem, Athens, OH 45701 USA

来源：

CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 41期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

GASTROINTESTINAL STROMAL TUMORS; TRANSITION-METAL-COMPLEXES; RUTHENIUM(II) COMPLEX; RU(II) COMPLEXES; PHOTOCHEMISTRY; INHIBITION; ACTIVATION; THERAPY; RELEASE; CD117;

D O I：

10.1039/c8cc01348a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Ru(ii)-polypyridyl cages with sterically bulky bidentate ligands provide efficient photochemical release of the anticancer drug imatinib using low energy visible light, imparting spatiotemporal control over drug bioavailability. The light-activated drug release is maintained when the Ru(ii) cage is covalently coupled to an antibody, which is expected to localize selectively on the tumor.

引用

页码：5193 / 5196

页数：4

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