Clinical significance of CD44 expression in children with hepatoblastoma

被引：5

作者：

Cai, H. -Y. ^{[1
]}

Yu, B. ^{[1
]}

Feng, Z. -C. ^{[2
]}

Qi, X. ^{[1
]}

Wei, X. -J. ^{[1
]}

机构：

[1] Gen Hosp Beijing Mil Reg, Dept Gen Surg, Beijing, Peoples R China

[2] Beijing Mil Gen Hosp, Ba Yi Childrens Hosp, 5 Nan Men Cang, Beijing, Peoples R China

来源：

GENETICS AND MOLECULAR RESEARCH | 2015年 / 14卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Hepatoblastoma; Antigens; CD44; Children; CANCER; CELLS;

D O I：

10.4238/2015.October.26.16

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The aim of this study was to investigate the expression of CD44 and its clinical significance in children suffering from hepatoblastoma (HB). CD44 expression was detected with immunohistochemistry staining in 30 samples from hepatoblastoma children and 10 normal liver tissue samples from normal children. The data obtained was statistically analyzed using the chi-square test, using the SPSS (v.11.0) software. The rate of CD44 expression was significantly higher (66.7%) in hepatoblastoma tissues than in normal liver tissues (chi(2) = 4.848, P < 0.05). The rate of CD44 expression was significantly higher in children with stage III or IV hepatoblastoma (83.3%) than that in children with stage I and II hepatoblastoma (chi(2) = 5.625, P < 0.05) (41.7%). Therefore, CD44 expression might play an important role in the pathogenesis, progression, and prognosis of HB in children.

引用

页码：13203 / 13207

页数：5

共 12 条

[1]

Cai HY, 2012, C J MED OFFICERS, V40, P851

[2]

Dong Q, 2005, PEDIAT HEPATOBILIARY, P227

[3] CD44 is of Functional Importance for Colorectal Cancer Stem Cells [J].

Du, Lei ;

Wang, Hongyi ;

He, Leya ;

Zhang, Jingyu ;

Ni, Biyun ;

Wang, Xiaohui ;

Jin, Haijing ;

Cahuzac, Nathalie ;

Mehrpour, Maryam ;

Lu, Youyong ;

Chen, Quan .

CLINICAL CANCER RESEARCH, 2008, 14 (21) :6751-6760

[4] Pediatric liver neoplasms: a radiologic-pathologic correlation [J].

Helmberger, TK ;

Ros, PR ;

Mergo, PJ ;

Tomczak, R ;

Reiser, MF .

EUROPEAN RADIOLOGY, 1999, 9 (07) :1339-1347

[5]

Herzog C E, 2000, Oncologist, V5, P445, DOI 10.1634/theoncologist.5-6-445

[6] The Role of CD44 in the Pathogenesis, Diagnosis, and Therapy of Gastric Cancer [J].

Jang, Byung Ik ;

Li, Yuan ;

Graham, David Y. ;

Cen, Putao .

GUT AND LIVER, 2011, 5 (04) :397-405

[7] Non-Small Cell Lung Cancer Cells Expressing CD44 Are Enriched for Stem Cell-Like Properties [J].

Leung, Elaine Lai-Han ;

Fiscus, Ronald R. ;

Tung, James W. ;

Tin, Vicky Pui-Chi ;

Cheng, Lik Cheung ;

Sihoe, Alan Dart-Loon ;

Fink, Louis M. ;

Ma, Yupo ;

Wong, Maria Pik .

PLOS ONE, 2010, 5 (11)

[8]

Louderbough Jeanne M V, 2011, Genes Cancer, V2, P771, DOI 10.1177/1947601911428223

[9] Complete Surgical Resection Is Curative for Children With Hepatoblastoma With Pure Fetal Histology: A Report From the Children's Oncology Group [J].

Malogolowkin, Marcio H. ;

Katzenstein, Howard M. ;

Meyers, Rebecka L. ;

Krailo, Mark D. ;

Rowland, Jon M. ;

Haas, Joel ;

Finegold, Milton J. .

JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (24) :3301-3306

[10] Novel dual cyclooxygenase and lipoxygenase inhibitors targeting hyaluronan-CD44v6 pathway and inducing cytotoxicity in colon cancer cells [J].

Misra, Suniti ;

Ghatak, Shibnath ;

Patil, Neha ;

Dandawate, Prasad ;

Ambike, Vinita ;

Adsule, Shreelekha ;

Unni, Deepak ;

Swamy, K. Venkateswara ;

Padhye, Subhash .

BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 21 (09) :2551-2559

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