An Efficient Approach to the Synthesis of Coumarin-Bearing 2,3-Dihydro-4(1H)-Quinazolinone Derivatives Using a Piperidine and Molecular Iodine Dual-Catalyst System

被引：15

作者：

Alizadeh, Abdolali ^{[1
]}

Ghanbaripour, Rashid ^{[1
]}

Zhu, Long-Guan ^{[2
]}

机构：

[1] Tarbiat Modares Univ, Dept Chem, Tehran, Iran

[2] Zhejiang Univ, Dept Chem, Hangzhou 310027, Zhejiang, Peoples R China

来源：

SYNLETT | 2014年 / 25卷 / 11期

关键词：

salicylaldehyde; beta-keto ester; isatoic anhydride; ammonium acetate; 2-alkyl-2-(2-oxo-2H-chromen-3-yl)-2,3-dihydro-4(1H)quinazolinone; dual-catalyst system; ONE-POT SYNTHESIS; BIOLOGICAL EVALUATION; KETOCOUMARINS; 2H-CHROMENES; QUINAZOLINE; ALDEHYDES; AMINES;

D O I：

10.1055/s-0033-1341202

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient dual-catalyst system of piperidine and molecular iodine has been developed for the synthesis of 2-alkyl-2(2-oxo-2H-chromen-3-yl)-2,3-dihydro-4(1H)quinazolinone derivatives by a four-component reaction of salicylaldehydes, beta-keto esters, ammonium acetate, and isatoic anhydride. Good yields, mild reaction conditions, and easy purification are attractive features of the present method.

引用

收藏

页码：1596 / 1600

页数：5

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