Photodynamic therapy and anti-tumour immunity

被引：2300

作者：

Castano, Ana P.

Mroz, Pawel

Hamblin, Michael R. ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA

[2] Harvard Univ, Sch Med, Dept Dermatol, Boston, MA 02115 USA

[3] Harvard Mit Div Hlth Sci & Technol, Cambridge, MA USA

来源：

NATURE REVIEWS CANCER | 2006年 / 6卷 / 07期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrc1894

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Photodynamic therapy (PDT) uses non-toxic photosensitizers and harmless visible light in combination with oxygen to produce cytotoxic reactive oxygen species that kill malignant cells by apoptosis and/or necrosis, shut down the tumour microvasculature and stimulate the host immune system. In contrast to surgery, radiotherapy and chemotherapy that are mostly immunosuppressive, PDT causes acute inflammation, expression of heat-shock proteins, invasion and infiltration of the tumour by leukocytes, and might increase the presentation of tumour-derived antigens to T cells.

引用

页码：535 / 545

页数：11

共 147 条

[1]

Abdel-Hady ES, 2001, CANCER RES, V61, P192

[2] Regulatory pathways in photodynamic therapy induced apoptosis [J].