Photodynamic therapy and anti-tumour immunity

被引:2250
作者
Castano, Ana P.
Mroz, Pawel
Hamblin, Michael R. [1 ]
机构
[1] Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA
[2] Harvard Univ, Sch Med, Dept Dermatol, Boston, MA 02115 USA
[3] Harvard Mit Div Hlth Sci & Technol, Cambridge, MA USA
基金
美国国家卫生研究院;
关键词
D O I
10.1038/nrc1894
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Photodynamic therapy (PDT) uses non-toxic photosensitizers and harmless visible light in combination with oxygen to produce cytotoxic reactive oxygen species that kill malignant cells by apoptosis and/or necrosis, shut down the tumour microvasculature and stimulate the host immune system. In contrast to surgery, radiotherapy and chemotherapy that are mostly immunosuppressive, PDT causes acute inflammation, expression of heat-shock proteins, invasion and infiltration of the tumour by leukocytes, and might increase the presentation of tumour-derived antigens to T cells.
引用
收藏
页码:535 / 545
页数:11
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