Assaying the DNA damage checkpoint in fission yeast

被引：12
|
作者：
Dunaway, S
Walworth, NC
机构：
[1] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Pharmacol, Piscataway, NJ 08854 USA
[2] Univ Med & Dent New Jersey, Grad Sch Biomed Sci, Joint Grad Program Cellular & Mol Pharmacol, Piscataway, NJ 08854 USA
[3] Rutgers State Univ, Piscataway, NJ 08854 USA
来源：
METHODS | 2004年 / 33卷 / 03期
关键词：
D O I：
10.1016/j.ymeth.2003.11.022
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Cell cycle checkpoints exist to ensure the proper maintenance and stable inheritance of genomic information. The pathways that insure the faithful execution of these checkpoints are well conserved throughout evolution. In the fission yeast, Schizosaccharomyces pombe, a major cell cycle checkpoint exists that responds to the presence of damaged DNA and prevents this damage from being propagated to future generations. Fission yeast is an ideal system to investigate these pathways because there exist specific techniques that allow one to assay the fidelity of this DNA damage checkpoint pathway. (C) 2003 Elsevier Inc. All rights reserved.
引用
收藏
页码：260 / 263
页数：4
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