Pericytes: multitasking cells in the regeneration of injured, diseased, and aged skeletal muscle

被引：109
作者：
Birbrair, Alexander [1 ,2 ]
Zhang, Tan [1 ]
Wang, Zhong-Min [1 ]
Messi, Maria L. [1 ]
Mintz, Akiva [3 ]
Delbono, Osvaldo [1 ,2 ]
机构：
[1] Wake Forest Sch Med, Dept Internal Med Gerontol, Winston Salem, NC 27157 USA
[2] Wake Forest Sch Med, Neurosci Program, Winston Salem, NC 27157 USA
[3] Wake Forest Sch Med, Dept Neurosurg, Winston Salem, NC 27157 USA
来源：
FRONTIERS IN AGING NEUROSCIENCE | 2014年 / 6卷
基金：
美国国家卫生研究院;
关键词：
pericytes; skeletal muscle; regeneration; innervation; fat formation; fibrous tissue; angiogenesis; aging; ENDOTHELIAL GROWTH-FACTOR; FIBRODYSPLASIA OSSIFICANS PROGRESSIVA; PERIPHERAL-NERVE REGENERATION; ISCHEMIA-INDUCED ANGIOGENESIS; TO-MESENCHYMAL TRANSITION; BOVINE RETINAL PERICYTES; RAT MEDIAL GASTROCNEMIUS; CRITICAL LIMB ISCHEMIA; BLOOD-VESSEL FORMATION; PDGF-ALPHA-RECEPTOR;
D O I：
10.3389/fnagi.2014.00245
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Pericytes are perivascular cells that envelop and make intimate connections with adjacent capillary endothelial cells. Recent studies show that they may have a profound impact in skeletal muscle regeneration, innervation, vessel formation, fibrosis, fat accumulation, and ectopic bone formation throughout life. In this review, we summarize and evaluate recent advances in our understanding of pericytes' influence on adult skeletal muscle pathophysiology. We also discuss how further elucidating their biology may offer new approaches to the treatment of conditions characterized by muscle wasting.
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页数：18
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