How NKG2D ligands trigger autoimmunity?

被引：53

作者：

Caillat-Zucman, Sophie ^{[1
]}

机构：

[1] Hop St Vincent de Paul, INSERM, U561, AVENIR Team, F-75674 Paris, France

来源：

HUMAN IMMUNOLOGY | 2006年 / 67卷 / 03期

关键词：

D O I：

10.1016/j.humimm.2006.02.013

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The function of NK and CD8 T cells in the elimination of infected, transformed, or stressed cells occurs together with tolerance to self, a property that is essential to prevent autoimmunity. Inappropriate expression of NK receptor ligands, leading to activation of autoreactive effector cells, might therefore trigger or exacerbate autoimmunity. We review here some recent data on the activating receptor NKG2D and its MIC ligand, which are indicative of their detrimental roles in some autoimmune disorders.

引用

页码：204 / 207

页数：4

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