How NKG2D ligands trigger autoimmunity?

被引：53
作者：
Caillat-Zucman, Sophie [1 ]
机构：
[1] Hop St Vincent de Paul, INSERM, U561, AVENIR Team, F-75674 Paris, France
来源：
HUMAN IMMUNOLOGY | 2006年 / 67卷 / 03期
关键词：
D O I：
10.1016/j.humimm.2006.02.013
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The function of NK and CD8 T cells in the elimination of infected, transformed, or stressed cells occurs together with tolerance to self, a property that is essential to prevent autoimmunity. Inappropriate expression of NK receptor ligands, leading to activation of autoreactive effector cells, might therefore trigger or exacerbate autoimmunity. We review here some recent data on the activating receptor NKG2D and its MIC ligand, which are indicative of their detrimental roles in some autoimmune disorders.
引用
收藏
页码：204 / 207
页数：4
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  • [1] Activation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICA
    Bauer, Stefan
    Groh, Veronika
    Wu, Jun
    Steinle, Alexander
    Phillips, Joseph H.
    Lanier, Lewis L.
    Spies, Thomas
    [J]. JOURNAL OF IMMUNOLOGY, 2018, 200 (07) : 2231 - 2233
  • [2] HLA-DRB1 and MHC class 1 chain-related A haplotypes in Basque families with celiac disease
    Bilbao, JR
    Martín-Pagola, A
    Vitoria, JC
    Zubillaga, P
    Ortiz, L
    Castaño, L
    [J]. TISSUE ANTIGENS, 2002, 60 (01): : 71 - 76
  • [3] The nonobese diabetic mouse as a model of autoimmune diabetes: Immune dysregulation gets the NOD
    Delovitch, TL
    Singh, B
    [J]. IMMUNITY, 1997, 7 (06) : 727 - 738
  • [4] Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D
    Diefenbach, A
    Tomasello, E
    Lucas, M
    Jamieson, AM
    Hsia, JK
    Vivier, E
    Raulet, DH
    [J]. NATURE IMMUNOLOGY, 2002, 3 (12) : 1142 - 1149
  • [5] Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rhe'umatoid arthritis
    Groh, V
    Brühl, A
    El-Gabalawy, H
    Nelson, JL
    Spies, T
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (16) : 9452 - 9457
  • [6] Association between the transmembrane region polymorphism of MHC class I chain related gene-A and type 1 diabetes mellitus in Sweden
    Gupta, M
    Nikitina-Zake, L
    Zarghami, M
    Landin-Olsson, M
    Kockum, I
    Lernmark, Å
    Sanjeevi, CB
    [J]. HUMAN IMMUNOLOGY, 2003, 64 (05) : 553 - 561
  • [7] A direct role for NKG2D/MICA interaction in villous atrophy during celiac disease
    Hüe, S
    Mention, JJ
    Monteiro, RC
    Zhang, SL
    Cellier, C
    Schmitz, J
    Verkarre, V
    Fodil, N
    Bahram, S
    Cerf-Bensussan, N
    Caillat-Zucman, S
    [J]. IMMUNITY, 2004, 21 (03) : 367 - 377
  • [8] NK cell recognition
    Lanier, LL
    [J]. ANNUAL REVIEW OF IMMUNOLOGY, 2005, 23 : 225 - 274
  • [9] Interleukin 15 mediates epithelial changes in celiac disease
    Maiuri, L
    Ciacci, C
    Auricchio, S
    Brown, V
    Quaratino, S
    Londei, M
    [J]. GASTROENTEROLOGY, 2000, 119 (04) : 996 - 1006
  • [10] Association between innate response to gliadin and activation of pathogenic T cells in coeliac disease
    Maiuri, L
    Ciacci, C
    Ricciardelli, I
    Vacca, L
    Raia, V
    Auricchio, S
    Picard, J
    Osman, M
    Quaratino, S
    Londei, M
    [J]. LANCET, 2003, 362 (9377) : 30 - 37
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