Inflammation-Based Scores: A New Method for Patient-Targeted Strategies and Improved Perioperative Outcome in Cancer Patients

被引:55
作者
Bugada, Dario [1 ,2 ]
Allegri, Massimo [2 ,3 ,4 ]
Lavand'homme, Patricia [5 ]
De Kock, Marc [5 ]
Fanelli, Guido [2 ,6 ]
机构
[1] Fdn IRCCS Policlin San Matteo, Dept Anaesthesia & Intens Care, I-27100 Pavia, Italy
[2] SIMPAR Study Multidisciplinary Pain Res Grp, Pavia, Italy
[3] Univ Pavia, Dept Surg Med Diagnost & Pediat Sci, I-27100 Pavia, Italy
[4] Fdn IRCCS Policlin San Matteo, PainTherapy Serv, I-27100 Pavia, Italy
[5] Catholic Univ Louvain, St Luc Hosp, Dept Anesthesia & Perioperat Med, B-1200 Brussels, Belgium
[6] Univ Parma, Dept Anesthesia & Intens Care, I-43126 Parma, Italy
关键词
TO-LYMPHOCYTE RATIO; PREOPERATIVE NEUTROPHIL/LYMPHOCYTE RATIO; UNRESECTABLE HEPATOCELLULAR-CARCINOMA; ENDOTHELIAL GROWTH-FACTOR; PREDICTS POOR SURVIVAL; SERUM CA19-9 LEVELS; SYSTEMIC INFLAMMATION; PLATELET COUNT; PRETREATMENT NEUTROPHIL; CURATIVE RESECTION;
D O I
10.1155/2014/142425
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Systemic inflammatory response (SIR) has actually been shown as an important prognostic factor associated with lower postoperative survival in several types of cancer. Thus, the challenge for physicians is to find specific, low-cost, and highlyreliable inflammatory markers, clearly correlated with prognosis and able to preoperatively stratify patient's risk. Inflammation is a promising target to improve perioperative outcome, and data show that anti-inflammation techniques have a great potential in the perioperative period of cancer surgery. Inflammation scores could be useful to stratify patients with a potential better response to anti-inflammation strategies. Furthermore, inflammation scores could prevent failure of clinical trials by a better definition of patients to be included in such trials; inflammation scoring could clarify the real role of different drugs and techniques on outcome after cancer surgery, defining if different therapies are required for different patients. The role of this review is to focus on the currently available scores, in order to clarify their rationale and to analyze the actual evidence and limits, providing physicians with an updated overview of the possible inflammation-based prognostic scores for cancer patients undergoing surgery.
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页数:11
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