Genetic Predisposition to Breast Cancer

被引：0
|
作者：
Boyd, Jeff [1 ,2 ]
机构：
[1] Temple Univ Hlth Syst, Fox Chase Canc Ctr, Canc Genome Inst, Dept Pathol, Philadelphia, PA USA
[2] Temple Univ Hlth Syst, Fox Chase Canc Ctr, Canc Biol Program, Philadelphia, PA USA
来源：
CANCER | 2014年 / 120卷 / 07期
关键词：
PALB2; MUTATIONS; SUSCEPTIBILITY; TWINS;
D O I：
10.1002/cncr.28503
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In the study by Fernandes et al in this issue, the largest cohort of patients with breast cancer studied to date was examined for mutations in the PALB gene, including all 13 coding exons and intron/exon junctions, using traditional Sanger sequencing. Future advances in our ability to develop primary and secondary approaches to breast cancer prevention will depend on new tools to test for polygenic determinants of breast cancer risk.
引用
收藏
页码：932 / 934
页数：3
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