High MYBL2 expression and transcription regulatory activity is associated with poor overall survival in patients with hepatocellular carcinoma

被引：43

作者：

Guan, Z. ^{[1
]}

Cheng, W. ^{[2
]}

Huang, D. ^{[3
]}

Wei, A. ^{[4
]}

机构：

[1] Guangxi Univ Chinese Med, Dept Hepatopathy, Affiliated Hosp 1, 89-9 Dongge Rd, Nanning 530023, Guangxi, Peoples R China

[2] Fourth Peoples Hosp Nanning, Dept Integrated Chinese & Western Med, Nanning 530023, Guangxi, Peoples R China

[3] Guangxi Med Univ, Affiliated Tumour Hosp, Dept Intervent Radiol, Nanning 530021, Guangxi, Peoples R China

[4] Guangxi Univ Chinese Med, Sch Continuing Educ, Nanning 530001, Guangxi, Peoples R China

来源：

CURRENT RESEARCH IN TRANSLATIONAL MEDICINE | 2018年 / 66卷 / 01期

关键词：

MYBL2; Prognosis; Transcription regulatory activity; Overall survival; Hepatocellular carcinoma; B-MYB; CANCER; COMPLEX; ACTIVATION; CONTRIBUTES; CELLS; FOXM1;

D O I：

10.1016/j.retram.2017.11.002

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Purpose. - In this study, we aimed to assess the association between MYBL2 expression/transcription regulatory activity (TRA) and overall survival (OS) in patients with primary hepatocellular carcinoma (HCC) and to explore the factors related to B-Myb TRA. Materials and methods. - Bioinformatic analysis was performed based on data from the cancer genome atlas-liver hepatocellular carcinoma (TCGA-LIHC) and the human protein atlas (HPA). Results. - The death group in TCGA-LIHC had significantly higher MYBL2 RNA and exon expression than the censor group. The high MYBL2 RNA and exon expression groups had significantly worse OS (P < 0.01). Univariate and multivariate analysis confirmed that high MYBL2 expression was an independent prognostic factor of unfavourable OS (HR = 1.591, 95% CI: 1.119-2.262, P = 0.01). One hundred and fourteen out of 188 primary HCC cases in TCGA-LIHC had elevated transcription of B-Myb's downstream genes. High B-Myb TRA was associated with poor OS (P = 0.013). Elevated expression of MYBL2, LIN9, LIN52 and FOXM1 were related to the higher TRA of B-Myb in HCC. Conclusion. - High MYBL2 expression/TRA are associated with inferior OS in patients with primary HCC. Increased expression of MYBL2, LIN9, LIN52 and FOXM1 are related to higher TRA of B-Myb in HCC. (C) 2017 Elsevier Masson SAS. All rights reserved.

引用

页码：27 / 32

页数：6

共 20 条

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