Communication between stromal and hematopoietic stem cell by exosomes in normal and malignant bone marrow niche

被引：18

作者：

Niazi, Vahid ^{[1
]}

Parseh, Benyamin ^{[2
]}

Ahani, Milad ^{[1
]}

Karami, Farshid ^{[1
]}

Gilanchi, Samira ^{[3
]}

Atarodi, Kamran ^{[4
]}

Soufi, Mina ^{[5
]}

Soleimani, Masoud ^{[5
]}

Ghafouri-Fard, Soudeh ^{[6
]}

Taheri, Mohammad ^{[7
]}

Zali, Hakimeh ^{[1
,8
]}

机构：

[1] Shahid Beheshti Univ Med Sci, Sch Adv Technol Med, Dept Tissue Engn & Appl Cell Sci, Tehran 1985717443, Iran

[2] Univ Tehran Med Sci, Sch Adv Technol Med, Dept Tissue Engn & Appl Cell Sci, Tehran 1417755469, Iran

[3] Shahid Beheshti Univ Med Sci, Fac Paramed Sci, Tehran 1971653313, Iran

[4] High Inst Res & Educ Transfus Med, Blood Transfus Res Ctr, Tehran 146651157, Iran

[5] Tarbiat Modares Univ, Fac Med Sci, Dept Hematol & Cell Therapy, Tehran 1411713116, Iran

[6] Shahid Beheshti Univ Med Sci, Dept Med Genet, Tehran, Iran

[7] Shahid Beheshti Univ Med Sci, Urogenital Stem Cell Res Ctr, Tehran, Iran

[8] Shahid Beheshti Univ Med Sci, Prote Res Ctr, Tehran 1971653313, Iran

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2020年 / 132卷

关键词：

Exosome; Hematopoietic stem cell; Bone marrow niche; Mesenchymal stem cells; Extracellular vehicles; TUMOR-DERIVED EXOSOMES; ACUTE MYELOID-LEUKEMIA; CHRONIC LYMPHOCYTIC-LEUKEMIA; REGULATORY T-CELLS; EXTRACELLULAR VESICLES; CIRCULATING MICROVESICLES; TRANSFERRIN RECEPTOR; MEMBRANE-VESICLES; INDUCE APOPTOSIS; IN-VITRO;

D O I：

10.1016/j.biopha.2020.110854

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Extracellular vesicles (EVs) have been regarded as important tools for cell-cell communication. They act as carriers for the transfer of various molecules such as genes, proteins and miRNA. EVs shift and transfer their ingredients to target cells in an active form. These particles have prominent roles in modulation of bone marrow (BM) niche; therefore they can regulate proliferation, differentiation, and other properties of hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs). This review discusses the different roles of EVs on BM niche; HPCs fate regulation and downstream effects of them on HSCs. Moreover, cellular and molecular mechanisms of BM microenvironment cross-talking are explained in healthy and malignant settings.

引用

页数：10

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