Studies on the resorcylates: biomimetic total syntheses of (+)-montagnetol and (+)-erythrin

被引：44

作者：

Basset, Jean-Francois ^{[1
]}

Leslie, Colin ^{[2
]}

Hamprecht, Dieter ^{[2
]}

White, Andrew J. P. ^{[1
]}

Barrett, Anthony G. M. ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AZ, England

[2] GlaxoSmithKline Ctr Ric, I-37135 Verona, Italy

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 05期

关键词：

D O I：

10.1016/j.tetlet.2009.11.134

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

6-(2,4-Dioxopentyl)-2,2-trimethyl-4H-1,3-dioxin-4-one on reflux in toluene gave MeCOCH2COCH2 COCH=C=O, which cyclized to 6-(2-oxopropyl)-4-hydroxy-2H-pyrin-2-one or was trapped with alcohols to produce resorcylate esters. The method was used for the synthesis of both enantiomers of montagnetol and erythrin. (c) 2009 Elsevier Ltd. All rights reserved.

引用

页码：783 / 785

页数：3

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