Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells

被引：148

作者：

Chen, Pei-Hsuan ^{[1
,11
]}

Cai, Ling ^{[1
,2
]}

Huffman, Kenneth ^{[3
]}

Yang, Chendong ^{[1
]}

Kim, Jiyeon ^{[1
,12
]}

Faubert, Brandon ^{[1
]}

Boroughs, Lindsey ^{[1
]}

Ko, Bookyung ^{[1
]}

Sudderth, Jessica ^{[1
]}

McMillan, Elizabeth A. ^{[4
]}

Girard, Luc ^{[3
,5
]}

Chen, Dong ^{[6
]}

Peyton, Michael ^{[3
]}

Shields, Misty D. ^{[3
]}

Yao, Bo ^{[2
]}

Shames, David S. ^{[7
]}

Kim, Hyun Seok ^{[4
,13
]}

Timmons, Brenda ^{[3
]}

Sekine, Ikuo ^{[3
]}

Britt, Rebecca ^{[3
,14
]}

Weber, Stephanie ^{[3
]}

Byers, Lauren A. ^{[8
]}

Heymach, John V. ^{[8
]}

Chen, Jing ^{[6
]}

White, Michael A. ^{[4
]}

Minna, John D. ^{[3
,5
,9
]}

Xiao, Guanghua ^{[2
]}

DeBerardinis, Ralph J. ^{[1
,10
]}

机构：

[1] UT Southwestern Med Ctr, Childrens Med Ctr, Res Inst, 5323 Harry Hines Blvd, Dallas, TX 75390 USA

[2] UT Southwestern Med Ctr, Dept Populat & Data Sci, Quantitat Biomed Res Ctr, 5323 Harry Hines Blvd, Dallas, TX 75390 USA

[3] Univ Texas Southwestern Med Ctr Dallas, Hamon Ctr Therapeut Oncol, 5323 Harry Hines Blvd, Dallas, TX 75390 USA

[4] UTSW Med Ctr, Dept Cell Biol, Dallas, TX 75390 USA

[5] Univ Texas Southwestern Med Ctr Dallas, Dept Pharmacol, 5323 Harry Hines Blvd, Dallas, TX 75390 USA

[6] Emory Univ, Winship Canc Inst, Atlanta, GA 30322 USA

[7] Genentech Inc, Dept Oncol Biomarker Dev, San Francisco, CA 94080 USA

[8] Univ Texas MD Anderson Canc Ctr, Dept Thorac Head & Neck Med Oncol, Houston, TX 77030 USA

[9] Univ Texas Southwestern Med Ctr Dallas, Dept Internal Med, 5323 Harry Hines Blvd, Dallas, TX 75390 USA

[10] Univ Texas Southwestern Med Ctr Dallas, Howard Hughes Med Inst, 5323 Harry Hines Blvd, Dallas, TX 75390 USA

[11] Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA

[12] Univ Illinois, Dept Biochem & Mol Genet, 900 S Ashland Ave, Chicago, IL 60607 USA

[13] Yonsei Univ, Coll Med, Severance Biomed Sci Inst, Brain Korea 21 Plus Project Med Sci, Seoul 120749, South Korea

[14] El Ctr Coll, 801 Main St, Dallas, TX 75202 USA

来源：

MOLECULAR CELL | 2019年 / 76卷 / 05期

关键词：

REDUCTIVE CARBOXYLATION; GLUTAMINE-METABOLISM; PYRUVATE-CARBOXYLASE; AEROBIC GLYCOLYSIS; TARGET; LKB1; DIFFERENTIATION; HETEROGENEITY; ANTIFOLATE; INHIBITOR;

D O I：

10.1016/j.molcel.2019.08.028

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Intermediary metabolism in cancer cells is regulated by diverse cell-autonomous processes, including signal transduction and gene expression patterns, arising from specific oncogenotypes and cell lineages. Although it is well established that metabolic reprogramming is a hallmark of cancer, we lack a full view of the diversity of metabolic programs in cancer cells and an unbiased assessment of the associations between metabolic pathway preferences and other cell-autonomous processes. Here, we quantified metabolic features, mostly from the C-13 enrichment of molecules from central carbon metabolism, in over 80 non-small cell lung cancer (NSCLC) cell lines cultured under identical conditions. Because these cell lines were extensively annotated for oncogenotype, gene expression, protein expression, and therapeutic sensitivity, the resulting database enables the user to uncover new relationships between metabolism and these orthogonal processes.

引用

页码：838 / +

页数：19

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