High prevalence of Mycoplasma genitalium infection and macrolide resistance in patients enrolled in HIV pre-exposure prophylaxis program

被引：18

作者：

Deborde, M. ^{[1
]}

Pereyre, S. ^{[2
,3
,4
]}

Puges, M. ^{[1
]}

Bebear, C. ^{[2
,3
,4
]}

Desclaux, A. ^{[1
]}

Hessamfar, M. ^{[5
,6
,7
]}

Le Roy, C. ^{[2
,3
]}

Le Marec, F. ^{[5
]}

Dabis, F. ^{[5
,6
]}

Cazanave, C. ^{[1
,2
,3
]}

机构：

[1] Bordeaux Univ Hosp, Pellegrin Hosp, Infect & Trop Dis Dept, F-33000 Bordeaux, France

[2] Bordeaux Univ, Mycoplasma & Chlamydia Human Infect, USC EA 3671, F-33000 Bordeaux, France

[3] French Natl Inst Agr Res, Mycoplasma & Chlamydia Human Infect, USC EA 3671, F-33000 Bordeaux, France

[4] Bordeaux Univ Hosp, Bacteriol Lab, F-33000 Bordeaux, France

[5] Bordeaux Univ, Inst Publ Hlth Epidemiol & Dev ISPED, Bordeaux Populat Hlth, Inserm U1219, F-33000 Bordeaux, France

[6] Bordeaux Univ Hosp, COREVIH Aquitaine, F-33000 Bordeaux, France

[7] Bordeaux Univ Hosp, St Andre Hosp, Infect Dis & Internal Med Dept, F-33000 Bordeaux, France

来源：

MEDECINE ET MALADIES INFECTIEUSES | 2019年 / 49卷 / 05期

关键词：

Pre-exposure prophylaxis; Mycoplastna genitalium; Macrolides; 2016 EUROPEAN GUIDELINE; MEN; SEX; ASSOCIATION; ASSAY; PCR;

D O I：

10.1016/j.medmal.2019.03.007

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Objectives. - Limited data on Mycoplasma genitalium infection has been reported among PrEP users. The aim of this study was to estimate the prevalence and macrolide resistance of M. genitalium infection among enrollees in a French PrEP program. Patients and methods. - M. genitalium infection screening was systematically and prospectively proposed to patients of the Bordeaux PrEP program (between January 2016 and February 2017). Macrolide resistance was evaluated in M. genitalium-positive patients. Results. - Among 89 clients, M. genitalium infection prevalence was 10% (mainly asymptomatic) with a high rate of macrolide resistance (58%). Conclusions. - Because of a high level of macrolide resistance, a systematic search for M. genitalium macrolide resistance associated-mutations may be recommended in PrEP users before initiating the antibiotic therapy. (C) 2019 Elsevier Masson SAS. All rights reserved.

引用

页码：347 / 349

页数：3

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