Cinnamon extract loaded electrospun chitosan/gelatin membrane with antibacterial activity

This study develops chitosan/gelatin nanofiber membranes with sustained release capacity to prevent infection by delivering cinnamon extract (CE) in the implanted site. The effects of the incorporation of CE content (2-6%) on the properties of the nanofibers were evaluated. Morphological studies using SEM indicated that loading the extract did not affect the average diameter of nanofiber mats, which remained around 140-170 nm. TGA and FTIR spectroscopy results confirmed successful CE loading. Furthermore, the results showed that incorporating extract into the nanofibers enhanced their degradation behavior, antibacterial activity, and biocompatibility. Cultured cells attached to and proliferate on the nanofiber membrane with high cell viability capacity until the CE content reached 4%. The extract release profile consisted of a burst release in the first 6 h, followed by a controlled release in the next 138 h. Therefore, CE loaded chitosan/gelatin nanofiber is an excellent construct for biomedical applications. (C) 2021 Elsevier B.V. All rights reserved.