Effects of grape pomace and seed polyphenol extracts on the recovery of gut microbiota after antibiotic treatment in high-fat diet-fed mice

被引：26
作者：
Lu, Feng [1 ,2 ]
Liu, Fengjiao [1 ,2 ]
Zhou, Qian [1 ,2 ]
Hu, Xiaosong [1 ,2 ]
Zhang, Yan [1 ,2 ]
机构：
[1] China Agr Univ, Coll Food Sci & Nutr Engn, Beijing 100083, Peoples R China
[2] Minist Sci & Technol, Natl Engn Res Ctr Fruits & Vegetables Proc, Beijing, Peoples R China
来源：
FOOD SCIENCE & NUTRITION | 2019年 / 7卷 / 09期
关键词：
antibiotics; grape pomace polyphenol extracts; grape seed polyphenol extracts; gut microbiota; high-fat diet; RED WINE POLYPHENOLS; INTESTINAL MICROBIOTA; METABOLISM; CHOLESTEROL; MICROFLORA; MODULATION;
D O I：
10.1002/fsn3.1141
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
The widespread use of antibiotics all over the world increases the risk of many metabolic diseases by altering the gut microbiota. Grape by-products are of particular interest in the prevention of metabolic diseases, while only minimum amounts of these wastes are up-graded or recycled at present. The study investigated the effect of grape pomace (GPE) and seed (GSE) polyphenol extracts on the recovery of gut microbiota after antibiotic cocktail treatment in high-fat diet-fed (HFD) mice. C57BL/6J mice were fed HFD together with antibiotic treatment by drinking water for 3 weeks. Then, GPE and GSE were supplemented for 7 days after withdrawal of antibiotics. The gut microbiota was characterized by a significant loss of diversity and certain important taxon after a 3-week antibiotic cocktail treatment. The GPE and GSE supplementation during the restore period of gut microbiota had some positive effects. The relative abundance of gut microbiota was improved by GPE and GSE compared to the spontaneous recovery group. And gut microbiota diversity was also greatly changed by GPE and GSE, being indicated by the changes of Verrucomicrobia and Akkermansia in feces. These findings suggested that grape polyphenol extracts have a great influence on the recovery of gut microbiota after antibiotics and high-fat diet treatment.
引用
收藏
页码：2897 / 2906
页数：10
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