The TNF-α-308G/A Polymorphism is Not Associated with Ocular Chlamydia trachomatis Infection in Han Chinese Children

被引：1
作者：
Xue, Wenwen [1 ,2 ]
Wang, Qingzhong [3 ]
Li, Zhiqiang [3 ]
Lu, Lina [1 ]
Zhu, Jianfeng [1 ]
He, Xiangui [1 ]
Zhao, Rong [1 ]
Shi, Yongyong [3 ]
Zou, Haidong [1 ,2 ]
机构：
[1] Shanghai Eye Dis Prevent & Treatment Ctr, Dept Preventat Ophthalmol, 380 Kangding Rd, Shanghai 200040, Peoples R China
[2] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 1, Dept Ophthalmol, Shanghai 200030, Peoples R China
[3] Shanghai Jiao Tong Univ, Minist Educ, BioX Inst, Key Lab Genet Dev & Neuropsychiat Disorders, Shanghai 200030, Peoples R China
来源：
OPHTHALMIC GENETICS | 2016年 / 37卷 / 02期
关键词：
Association; chinese population; TNF-alpha-308G/A; trachoma; NECROSIS-FACTOR-ALPHA;
D O I：
10.3109/13816810.2015.1028650
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Objective: To investigate the association between the TNF-alpha-308G/A polymorphism and ocular chlamydia trachomatis (C. Trachomatis) infection among Han Chinese children. Methods: 248 patients and 162 matched healthy controls were recruited. The diagnosis of ocular C. Trachomatis infection was given after clinical observation and latex immunochromatography tests. The TNF-alpha-308G/A polymorphism was genotyped by sequencing. Results: No association was found between the TNF-alpha-308G/A polymorphism and ocular C. Trachomatis infection. Conclusions: The TNF-alpha-308A polymorphism is unlikely to play a major role in the risk for ocular C. Trachomatis in the Chinese population.
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收藏
页码：245 / 247
页数：3
相关论文
共 14 条
  • [1] The Global Burden of Trachoma: A Review
    Burton, Matthew J.
    Mabey, David C. W.
    [J]. PLOS NEGLECTED TROPICAL DISEASES, 2009, 3 (10):
  • [2] Cavet ME, 2013, MOL VIS, V19, P1515
  • [3] Scarring trachoma is associated with polymorphism in the tumor necrosis factor alpha (TNF-alpha) gene promoter and with elevated TNF-alpha levels in tear fluid
    Conway, DJ
    Holland, MJ
    Bailey, RL
    Campbell, AE
    Mahdi, OSM
    Jennings, R
    Mbena, E
    Mabey, DCW
    [J]. INFECTION AND IMMUNITY, 1997, 65 (03) : 1003 - 1006
  • [4] Does inhibition of tumor necrosis factor alpha affect chlamydial genital tract infection in mice and guinea pigs?
    Darville, T
    Andrews, CW
    Rank, RG
    [J]. INFECTION AND IMMUNITY, 2000, 68 (09) : 5299 - 5305
  • [5] Conjunctival fibrosis in ocular cicatricial pemphigoid - the role of cytokines
    Elder, MJ
    Dart, JKG
    Lightman, S
    [J]. EXPERIMENTAL EYE RESEARCH, 1997, 65 (02) : 165 - 176
  • [6] Hu S, 2009, WORLD CHIN J DIG CHI, V17, P2079, DOI DOI 10.11569/wcjd.v17.i20.2079
  • [7] Human Female Genital Tract Infection by the Obligate Intracellular Bacterium Chlamydia trachomatis Elicits Robust Type 2 Immunity
    Miguel, Rodolfo D. Vicetti
    Harvey, Stephen A. K.
    LaFramboise, William A.
    Reighard, Seth D.
    Matthews, Dean B.
    Cherpes, Thomas L.
    [J]. PLOS ONE, 2013, 8 (03):
  • [8] Trachoma:: The forgotten cause of blindness
    Muñoz, B
    West, S
    [J]. EPIDEMIOLOGIC REVIEWS, 1997, 19 (02) : 205 - 217
  • [9] Genetic variation at the TNF locus and the risk of severe sequelae of ocular Chlamydia trachomatis infection in Gambians
    Natividad, A.
    Hanchard, N.
    Holland, M. J.
    Mahdi, O. S. M.
    Diakite, M.
    Rockett, K.
    Jallow, O.
    Joof, H. M.
    Kwiatkowski, D. P.
    Mabey, D. C. W.
    Bailey, R. L.
    [J]. GENES AND IMMUNITY, 2007, 8 (04) : 288 - 295
  • [10] Prevalence of Trachoma in the Far North Region of Cameroon: Results of a Survey in 27 Health Districts
    Noatina, Blaise Noa
    Kagmeni, Giles
    Mengouo, Marcellin Nimpa
    Moungui, Henri Claude
    Tarini, Ann
    Zhang, Yaobi
    Bella, Assumpta Lucienne Francoise
    [J]. PLOS NEGLECTED TROPICAL DISEASES, 2013, 7 (05):
12