Synthesis of new (difluoromethylphosphono)azadisaccharides designed as bisubstrate analogue inhibitors for GlcNAc:β-1,4 glycosyltransferases

被引：30
作者：
Gautier-Lefebvre, I
Behr, JB
Guillerm, G
Ryder, NS
机构：
[1] UFR Sci, Chim Bioorgan Lab, UMR 6519, F-51687 Reims 2, France
[2] Novartis Res Inst, A-1235 Vienna, Austria
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 13期
关键词：
D O I：
10.1016/S0960-894X(00)00263-8
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
We report here the design, synthesis and antifungal evaluation of a new model of bisubstrate analogue inhibitor for glycosyltransferases. The synthetic strategy relies on the reductive amination between the aldehyde derived from an N-allylphosphono-pyrrolidine and an aminosugar. (C) 2000 Elsevier Science Ltd. All rights reserved.
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页码：1483 / 1486
页数：4
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