Adipose tissue-derived mesenchymal stem cells ameliorate bone marrow aplasia related with graft-versus-host disease in experimental murine models

被引：8
作者：
Nishi, Yukiko [1 ]
Murakami, Akikazu [2 ]
Murayama, Yuko [1 ]
Tsukahara, Narutoshi [2 ]
Okamoto, Shiki [1 ]
Nakachi, Sawako [1 ]
Morichika, Kazuho [1 ]
Tamaki, Keita [1 ]
Noguchi, Hirofumi [3 ]
Matsushita, Masayuki [4 ]
Karube, Ken-Nosuke [5 ]
Fukushima, Takuya [6 ]
Morishima, Satoko [1 ]
Kishimoto, Hidehiro [2 ]
Masuzaki, Hiroaki [1 ]
机构：
[1] Univ Ryukyus, Grad Sch Med, Dept Internal Med 2, Div Endocrinol Diabet & Metab,Hematol,Rheumatol, 207 Uehara, Nishihara, Okinawa 9030215, Japan
[2] Univ Ryukyus, Grad Sch Med, Dept Parasitol & Immunopathoetiol, Okinawa, Japan
[3] Univ Ryukyus, Grad Sch Med, Dept Regenerat Med, Okinawa, Japan
[4] Univ Ryukyus, Grad Sch Med, Dept Mol & Cellular Physiol, Okinawa, Japan
[5] Univ Ryukyus, Grad Sch Med, Dept Pathol & Cell Biol, Okinawa, Japan
[6] Univ Ryukyus, Fac Med, Sch Hlth Sci, Lab Hematoimmunol, Okinawa, Japan
来源：
TRANSPLANT IMMUNOLOGY | 2019年 / 55卷
基金：
日本学术振兴会;
关键词：
Adipose tissue derived mesenchymal stem cells; Graft-versus-host disease; Bone marrow; Aplasia; STEROID-REFRACTORY ACUTE; ACUTE GVHD; STROMAL CELLS; THERAPY; TRANSPLANTATION; ENGRAFTMENT; RESISTANT; ANTIBODY; TREAT;
D O I：
10.1016/j.trim.2019.03.004
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Graft-versus-host disease (GVHD) constitutes the most frequent complications after the allogeneic hematopoietic stem cell transplantation for a variety of hematological malignancies. In the present study, we explored the prophylactic potential of adipose tissue-derived mesenchymal stem cells (AD-MSCs) in controlling GVHD in murine models with a special focus on bone marrow aplasia related with acute GVHD. The CB6F1 mice were induced GVHD by the injection intravenously of C57BL/6 (B6-Ly-5.1) splenocytes without conditioning irradiation or chemotherapy. AD-MSCs from C3H mice were injected intravenously via tail veins. GVHD was assessed using flowcytometry analysis of peripheral blood cells and histopathologic analysis of target organs. Histopathological analyses revealed that AD-MSCs markedly suppressed the infiltration of lymphocytes into liver as well as the aplasia in bone marrow. This study is the first to clarify the effectiveness of AD-MSCs against bone marrow aplasia in GVHD, supporting a rationale of AD-MSCs for ameliorating bone marrow suppression and infectivity after allo-HSCT in human clinics.
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页数：10
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