Lasting Effects of Intrauterine Exposure to Preeclampsia on Offspring and the Underlying Mechanism

被引:58
作者
Lu, Hui Qing [1 ]
Hu, Rong [1 ]
机构
[1] Fudan Univ, Hosp Obstet & Gynecol, Dept Obstet, Shanghai, Peoples R China
来源
AJP REPORTS | 2019年 / 9卷 / 03期
基金
中国国家自然科学基金;
关键词
Preeclampsia Offspring; cardiovascular system; neurological disorders; metabolism; DOHaD; PLACENTAL GROWTH-FACTOR; LOW-BIRTH-WEIGHT; CONGENITAL HEART-DEFECTS; ELEVATED BLOOD-PRESSURE; HYPERTENSIVE DISORDERS; BRAIN-DEVELOPMENT; GESTATIONAL HYPERTENSION; CARDIOVASCULAR-DISEASES; RECEPTOR EXPRESSION; ADULT HYPERTENSION;
D O I
10.1055/s-0039-1695004
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Preeclampsia is a common pregnancy complication which can have adverse impact on both mother and baby. In addition to the short term effects, a large body of epidemiological evidence has found preeclampsia can exert long-lasting effects on mother and offspring. Studies suggest that offspring exposed to preeclampsia are at a higher risk of developing cardiovascular, metabolic, and neurological diseases, as well as other diseases. However, studies investigating the underlying mechanism are limited, the exact mechanism still remains unclear. In this study, we will review the epidemiological evidence and studies exploring the mechanism underlying long-term effects of preeclampsia on offspring. Further studies should be targeted at this field so as to implement effective clinical management to prevent the exposed offspring from potential diseases.
引用
收藏
页码:E275 / E291
页数:17
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