Preparation and Characterization of Holmium-2-Hydroxypropyl β-Cyclodextrin Inclusion Complex and Its Stability under Gamma Radiation

被引：0
|
作者：
Lopez-Gonzalez, H. [1 ]
Jimenez-Becerril, J. [1 ]
Bautista-Santiago, C. [1 ]
Rojas-Hernandez, A. [2 ]
机构：
[1] Inst Nacl Invest Nucl, Dept Quim, Direcc Invest Cient, Gerencia Ciencias Bas, Mexico City 11801, Mexico
[2] Univ Autonoma Metropolitana Iztapalapa, Dept Quim, Area Quim Analit, Mexico City 09340, Mexico
来源：
RADIOCHEMISTRY | 2022年 / 64卷 / 06期
关键词：
holmium; 2-hydroxypropyl beta-cyclodextrin; inclusion complex; stability; gamma radiation; HOLMIUM NITRATE; 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN; NANOPARTICLES; GEL;
D O I：
10.1134/S1066362222060133
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The holmium inclusion complex with 2-hydroxypropyl beta-cyclodextrin (Ho-2-HP-beta-CD) was prepared and characterized by X-ray diffraction, IR and Raman spectroscopy, and thermogravimetric analysis. The preparation process involves the reaction of a solution of Ho(NO3)(3)center dot 5H(2)O with an aqueous solution of the 2-hydroxypropyl beta-cyclodextrin (2-HP-beta-CD). The compound's stability under gamma radiation in the range from 1 to 10000 Gy was studied. Only UV spectrophotometry reveals changes in the Ho-2-HP-beta-CD inclusion complex at the highest gamma radiation dose used. The stability at low doses and high solubility make Ho-2-HP-beta-CD inclusion complex a compound of interest in the new applications of lanthanides as therapeutic and biomedical agents.
引用
收藏
页码：757 / 765
页数：9
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