Preliminary report: No association between TCF7L2 rs7903146 and euglycemic-clamp-derived insulin sensitivity in a mixed-age cohort

被引：12

作者：

Rasmussen-Torvik, Laura J. ^{[1
]}

Pankow, James S.

Jacobs, David R., Jr. ^{[2
]}

Sinaiko, Alan R. ^{[3
]}

机构：

[1] Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN 55454 USA

[2] Univ Oslo, Dept Nutr, N-0316 Oslo, Norway

[3] Univ Minnesota, Dept Pediat, Minneapolis, MN 55455 USA

来源：

METABOLISM-CLINICAL AND EXPERIMENTAL | 2009年 / 58卷 / 10期

基金：

美国国家卫生研究院;

关键词：

GENE POLYMORPHISMS; SECRETION; RESISTANCE; RISK;

D O I：

10.1016/j.metabol.2009.04.023

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There are conflicting reports about the significance of TCF7L2 single nucleotide polymorphism rs7903146, a single nucleotide polymorphism found to be associated with type 2 diabetes mellitus in several genomewide association studies, and insulin sensitivity. The association of rs7903146 and euglycemic-clamp-derived insulin sensitivity was tested in a cohort of children and their parents. Four hundred seventy whites (front 226 families) and 89 African Americans (from 48 families) were included in the analysis. No significant associations were seen between rs7903146 and insulin sensitivity. Adjusted genotype means were consistent across races and generational subgroups. (c) 2009 Elsevier Inc. All rights reserved.

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收藏

页码：1369 / 1371

页数：3

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