From meiosis to postmeiotic events: The secrets of histone disappearance

被引:129
作者
Gaucher, Jonathan [1 ]
Reynoird, Nicolas [1 ]
Montellier, Emilie [1 ]
Boussouar, Faycal [1 ]
Rousseaux, Sophie [1 ]
Khochbin, Saadi [1 ]
机构
[1] Univ Grenoble 1, INSERM, Inst Albert Bonniot, U823, F-38700 Grenoble, France
关键词
acetylation; chromatin; epigenetics; histone variants; nucleosomes; protamines; protease; sperm; transition proteins; TRANSITION NUCLEAR PROTEINS; CHROMATIN CONDENSATION; SPERMATID CHROMATIN; DISTINCT PROTAMINES; WINTER FLOUNDER; NUCLEOSOME; SPERMIOGENESIS; ACETYLATION; SPERMATOGENESIS; TESTIS;
D O I
10.1111/j.1742-4658.2009.07504.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
One of the most obscure phenomena in modern biology is the near genome-wide displacement of histones that occurs during the postmeiotic phases of spermatogenesis in many species. Here we review the literature to show that, during spermatogenic differentiation, three major molecular mechanisms come together to 'prepare' the nucleosomes for facilitated disassembly and histone removal.
引用
收藏
页码:599 / 604
页数:6
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