Life cycles of successful genes

被引：42

作者：

Hoffmann, R ^{[1
]}

Valencia, A ^{[1
]}

机构：

[1] CSIC, CNB, Natl Ctr Biotechnol, M-28049 Madrid, Spain

来源：

TRENDS IN GENETICS | 2003年 / 19卷 / 02期

关键词：

D O I：

10.1016/S0168-9525(02)00014-8

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

By exploring time-series data from MEDLINE abstracts, we observe that only a few genes have been quoted with increasing frequency during the past 25 years. This is probably the result of selective pressure by the scientific community. Over the years, this selection has produced an extreme power law distribution of the information available for individual genes. Interestingly, those genes that are successfully selected are not necessarily the most important genes to the cell. To stress the implication of this finding we show that there is no correlation between a gene's impact in the scientific literature and its centrality in protein-interaction networks.

引用

页码：79 / 81

页数：3

共 9 条

[1] SELF-ORGANIZED CRITICALITY [J].

BAK, P ;

TANG, C ;

WIESENFELD, K .

PHYSICAL REVIEW A, 1988, 38 (01) :364-374

[2]

Bak P. P., 1996, NATURE WORKS

[3]

Dawkins R, 1989, SELFISH GENE

[4] Evolutionary rate in the protein interaction network [J].

Fraser, HB ;

Hirsh, AE ;

Steinmetz, LM ;

Scharfe, C ;

Feldman, MW .

SCIENCE, 2002, 296 (5568) :750-752

[5] A literature network of human genes for high-throughput analysis of gene expression [J].

Jenssen, TK ;

Lægreid, A ;

Komorowski, J ;

Hovig, E .

NATURE GENETICS, 2001, 28 (01) :21-+

[6] Lethality and centrality in protein networks [J].

Jeong, H ;

Mason, SP ;

Barabási, AL ;

Oltvai, ZN .

NATURE, 2001, 411 (6833) :41-42

[7]

MILGRAM S, 1967, PSYCHOL TODAY, V1, P61

[8] The structure of scientific collaboration networks [J].

Newman, MEJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (02) :404-409

[9] Comparative assessment of large-scale data sets of protein-protein interactions [J].

von Mering, C ;

Krause, R ;

Snel, B ;

Cornell, M ;

Oliver, SG ;

Fields, S ;

Bork, P .

NATURE, 2002, 417 (6887) :399-403

← 1 →