DNA Methylation in Early Development

被引：98

作者：

Geiman, Theresa M. ^{[1
]}

Muegge, Kathrin ^{[1
]}

机构：

[1] NCI, Lab Canc Prevent, SAIC Frederick, Frederick, MD 21702 USA

来源：

MOLECULAR REPRODUCTION AND DEVELOPMENT | 2010年 / 77卷 / 02期

基金：

美国国家卫生研究院;

关键词：

X-CHROMOSOME INACTIVATION; EMBRYONIC STEM-CELLS; DE-NOVO METHYLATION; CPG BINDING-PROTEIN; RETT-SYNDROME; PREIMPLANTATION DEVELOPMENT; IMMUNODEFICIENCY SYNDROME; METHYLTRANSFERASE GENE; EPIGENETIC INHERITANCE; MAMMALIAN DEVELOPMENT;

D O I：

10.1002/mrd.21118

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Development from separate parental germ cells through fertilization and proceeding to a fully functioning adult animal occurs through an intricate program of transcriptional and chromatin changes. Epigenetic alterations such as DNA methylation are an important part of this process. This review looks at the role of DNA methylation in early embryonic development, as well as how this epigenetic mark affects stem cell differentiation and tissue-specific gene expression in somatic cells.

引用

页码：105 / 113

页数：9

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