Bioprivileged molecules: creating value from biomass

被引:143
作者
Shanks, Brent H. [1 ,2 ]
Keeling, Peter L. [1 ]
机构
[1] Iowa State Univ, Ctr Biorenewable Chem CBiRC, Ames, IA 50011 USA
[2] Iowa State Univ, Dept Chem & Biol Engn, Ames, IA 50011 USA
基金
美国国家科学基金会;
关键词
TRIACETIC ACID LACTONE; DIVERSITY-ORIENTED SYNTHESIS; BUILDING-BLOCK CHEMICALS; SACCHAROMYCES-CEREVISIAE; MUCONIC ACID; PRIVILEGED STRUCTURES; BIOLOGICAL CATALYSIS; COMPUTATIONAL TOOLS; METABOLIC NETWORKS; SYNTHETIC BIOLOGY;
D O I
10.1039/c7gc00296c
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The petrochemical industry is built on C2-C4 alkenes and aromatics as intermediate molecules, which are converted to a range of products. This industry is highly developed with little opportunity for new chemical products. In comparison biological-derived intermediates from biomass have the potential to introduce a new set of intermediate molecules, which can be converted to molecules that directly replace petrochemicals. Even more promising is the potential to convert biological-derived intermediates to novel chemical species that impart enhanced performance properties in their end use. Here the concept of bioprivileged molecules is introduced as a useful new paradigm for developing biobased chemicals. Included are muconic acid, 5-hydroxymethylfurfural and triacetic acid lactone as example bioprivileged molecules. Also, discussed is the research needed to move this concept forward.
引用
收藏
页码:3177 / 3185
页数:9
相关论文
共 65 条
[11]   Biorefineries for the production of top building block chemicals and their derivatives [J].
Choi, Sol ;
Song, Chan Woo ;
Shin, Jae Ho ;
Lee, Sang Yup .
METABOLIC ENGINEERING, 2015, 28 :223-239
[12]   Synthetic and systems biology for microbial production of commodity chemicals [J].
Chubukov, Victor ;
Mukhopadhyay, Aindrila ;
Petzold, Christopher J. ;
Keasling, Jay D. ;
Martin, Hector Garcia .
NPJ SYSTEMS BIOLOGY AND APPLICATIONS, 2016, 2
[13]   Computational tools for metabolic engineering [J].
Copeland, Wilbert B. ;
Bartley, Bryan A. ;
Chandran, Deepak ;
Galdzicki, Michal ;
Kim, Kyung H. ;
Sleight, Sean C. ;
Maranas, Costas D. ;
Sauro, Herbert M. .
METABOLIC ENGINEERING, 2012, 14 (03) :270-280
[14]  
Coudray L, 2012, WO, Patent No. 2012141997
[15]   Metabolic engineering of muconic acid production in Saccharomyces cerevisiae [J].
Curran, Kathleen A. ;
Leavitt, Johnm. ;
Karim, AshtyS. ;
Alper, Hal S. .
METABOLIC ENGINEERING, 2013, 15 :55-66
[16]   A unified lead-oriented synthesis of over fifty molecular scaffolds [J].
Doveston, Richard G. ;
Tosatti, Paolo ;
Dow, Mark ;
Foley, Daniel J. ;
Li, Ho Yin ;
Campbell, Amanda J. ;
House, David ;
Churcher, Ian ;
Marsden, Stephen P. ;
Nelson, Adam .
ORGANIC & BIOMOLECULAR CHEMISTRY, 2015, 13 (03) :859-865
[17]   ENVIRONMENTALLY COMPATIBLE SYNTHESIS OF ADIPIC ACID FROM D-GLUCOSE [J].
DRATHS, KM ;
FROST, JW .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (01) :399-400
[18]   Privileged structures: A useful concept for the rational design of new lead drug candidates [J].
Duarte, Carolina D. ;
Barreiro, Eliezer J. ;
Fraga, Carlos A. M. .
MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2007, 7 (11) :1108-1119
[19]  
Dunlop W. R., 1982, U.S. Patent, Patent No. [US 4,318,999 A, 4318999]
[20]   METHODS FOR DRUG DISCOVERY - DEVELOPMENT OF POTENT, SELECTIVE, ORALLY EFFECTIVE CHOLECYSTOKININ ANTAGONISTS [J].
EVANS, BE ;
RITTLE, KE ;
BOCK, MG ;
DIPARDO, RM ;
FREIDINGER, RM ;
WHITTER, WL ;
LUNDELL, GF ;
VEBER, DF ;
ANDERSON, PS ;
CHANG, RSL ;
LOTTI, VJ ;
CERINO, DJ ;
CHEN, TB ;
KLING, PJ ;
KUNKEL, KA ;
SPRINGER, JP ;
HIRSHFIELD, J .
JOURNAL OF MEDICINAL CHEMISTRY, 1988, 31 (12) :2235-2246