Recent Achievements in Medicinal and Supramolecular Chemistry of Betulinic Acid and Its Derivatives

被引：49
|
作者：
Bildziukevich, Uladzimir [1 ,2 ]
Ozdemir, Zulal [1 ,2 ]
Wimmer, Zdenek [1 ,2 ]
机构：
[1] Czech Acad Sci, Inst Expt Bot, Isotope Lab, Videnska 1083, Prague 14220 4, Czech Republic
[2] Univ Chem & Technol Prague, Dept Chem Nat Cpds, Tech 5, Prague 16628 6, Czech Republic
来源：
MOLECULES | 2019年 / 24卷 / 19期
关键词：
betulinic acid; structural modification; supramolecular self-assembly; cytotoxicity; antitumor activity; antiviral activity; physicochemical parameters; ADME parameters; CARBON-DIOXIDE EXTRACTION; ANTI-AIDS AGENTS; HUMAN-MELANOMA; MATURATION INHIBITOR; ANTIVIRAL ACTIVITY; BETA-SITOSTEROL; POTENT; VIRUS; DISCOVERY; AMIDES;
D O I：
10.3390/molecules24193546
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The subject of this review article refers to the recent achievements in the investigation of pharmacological activity and supramolecular characteristics of betulinic acid and its diverse derivatives, with special focus on their cytotoxic effect, antitumor activity, and antiviral effect, and mostly covers a period 2015-2018. Literature sources published earlier are referred to in required coherences or from historical points of view. Relationships between pharmacological activity and supramolecular characteristics are included if such investigation has been done in the original literature sources. A wide practical applicability of betulinic acid and its derivatives demonstrated in the literature sources is also included in this review article. Several literature sources also focused on in silico calculation of physicochemical and ADME parameters of the developed compounds, and on a comparison between the experimental and calculated data.
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页数：20
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