Inhibitory effect of corynoline isolated from the aerial parts of Corydalis incisa on the acetylcholinesterase

被引：37
作者：
Kim, DK [1 ]
机构：
[1] Woosuk Univ, Coll Pharm, Samrye 565701, South Korea
来源：
ARCHIVES OF PHARMACAL RESEARCH | 2002年 / 25卷 / 06期
关键词：
Corydalis incisa; Papaveraceae; acetylcholinesterase inhibitor; corynoline;
D O I：
10.1007/BF02976997
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
In the course of screening Korean natural products for acetylcholinesterase (AChE) inhibitory activity, it was found that a methanolic extract of the aerial parts of Corydalis incisa (Papaveraceae) showed significant inhibitory effects on AChE. Corynoline isolated from this plant inhibited AChE activity in a dose-dependent manner, and the IC50 value of corynoline was 30.6 muM. The AChE inhibitory activity of corynoline was reversible and noncompetitive.
引用
收藏
页码：817 / 819
页数：3
相关论文
共 12 条
[1]   On neurodegenerative diseases, models, and treatment strategies: Lessons learned and lessons forgotten a generation following the cholinergic hypothesis [J].
Bartus, RT .
EXPERIMENTAL NEUROLOGY, 2000, 163 (02) :495-529
[2]   THE CHOLINERGIC HYPOTHESIS OF GERIATRIC MEMORY DYSFUNCTION [J].
BARTUS, RT ;
DEAN, RL ;
BEER, B ;
LIPPA, AS .
SCIENCE, 1982, 217 (4558) :408-417
[3]   SERUM-PROTEINS BYPASS THE BLOOD-BRAIN FLUID BARRIERS FOR EXTRACELLULAR ENTRY TO THE CENTRAL-NERVOUS-SYSTEM [J].
BROADWELL, RD ;
SOFRONIEW, MV .
EXPERIMENTAL NEUROLOGY, 1993, 120 (02) :245-263
[4]  
Chung YK, 2001, MOL CELLS, V11, P137
[5]   A NEW AND RAPID COLORIMETRIC DETERMINATION OF ACETYLCHOLINESTERASE ACTIVITY [J].
ELLMAN, GL ;
COURTNEY, KD ;
ANDRES, V ;
FEATHERSTONE, RM .
BIOCHEMICAL PHARMACOLOGY, 1961, 7 (02) :88-&
[6]   Benzo[c]phenanthridine alkaloids from Corydalis incisa [J].
Kim, DK ;
Eun, JS ;
Shin, TY ;
Eom, DO ;
Lim, JP .
ARCHIVES OF PHARMACAL RESEARCH, 2000, 23 (06) :589-591
[7]   Novel anticholinesterase and antiamnesic activities of dehydroevodiamine, a constituent of Evodia rutaecarpa [J].
Park, CH ;
Kim, SH ;
Choi, W ;
Lee, YJ ;
Kim, JS ;
Kang, SS ;
Suh, YH .
PLANTA MEDICA, 1996, 62 (05) :405-409
[8]   THE CHOLINERGIC HYPOTHESIS - 10 YEARS ON [J].
PERRY, EK .
BRITISH MEDICAL BULLETIN, 1986, 42 (01) :63-69
[9]   Screening for acetylcholinesterase inhibitors from Amaryllidaceae using silica gel thin-layer chromatography in combination with bioactivity staining [J].
Rhee, IK ;
van de Meent, M ;
Ingkaninan, K ;
Verpoorte, R .
JOURNAL OF CHROMATOGRAPHY A, 2001, 915 (1-2) :217-223
[10]  
RIGER F, 1980, DEV BIOL, V76, P238
12