An efficient, microwave-assisted, one-pot synthesis of indoles under Sonogashira conditions

被引：57
|
作者：
Chen, Yu [1 ]
Markina, Nataliya A. [1 ]
Larock, Richard C. [1 ]
机构：
[1] Iowa State Univ, Dept Chem, Ames, IA 50011 USA
来源：
TETRAHEDRON | 2009年 / 65卷 / 44期
基金：
美国国家卫生研究院;
关键词：
Microwave-assisted; One-pot; Three-component coupling; Indoles; Sonogashira coupling; PALLADIUM-CATALYZED CYCLIZATION; O-ALKYNYLTRIFLUOROACETANILIDES; ELECTROPHILIC CYCLIZATION; 2,3-DISUBSTITUTED INDOLES; INTERNAL ALKYNES; ARYL; CHEMISTRY; HALIDES; 3-IODOINDOLES; HETEROCYCLES;
D O I：
10.1016/j.tet.2009.07.075
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A microwave-assisted, one-pot, three-component coupling reaction for the synthesis of indoles has been developed. The reaction is carried out in two steps under standard Sonogashira coupling conditions from an N-substituted/N,N-disubstituted 2-iodoaniline and a terminal alkyne, followed by the addition of acetonitrile and an aryl iodide. A variety of polysubstituted indoles have been prepared in moderate to excellent yields using the present method. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：8908 / 8915
页数：8
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