A neoantigenic determinant in the D-dimer fragment of fibrin

被引：10
作者：
Lugovskoy, EV
Kolesnikova, IN
Gritsenko, PG
Zolotareva, EN
Gaffney, P
Nieuwenhuizen, W
Komisarenko, SV
机构：
[1] Natl Acad Sci Ukraine, AV Palladin Biochem Inst, UA-01601 Kiev, Ukraine
[2] Natl Inst Biol Stand & Controls, Potters Bar EN6 3QG, Herts, England
[3] TNO, Prevent & Hlth Gaubius Lab, NL-2301 CE Leiden, Netherlands
来源：
THROMBOSIS RESEARCH | 2002年 / 107卷 / 3-4期
关键词：
fibrin; D-dimer; neoantigenic determinant; monoclonal antibody;
D O I：
10.1016/S0049-3848(02)00204-9
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Monoclonal antibody (mAb) III-3b binds D-dimer with K-d = 1.4 x 10(-10) M without cross-reaction with fibrin(ogen). The epitope for this mAb is in Bbeta134-190, presumably in Bbeta155-160. The latter site is buried in the coiled coil structure of fibrin(ogen) but it is exposed as a neoantigenic determinant in D-dimer upon plasmic lysis of fibrin. mAb III-3b may be used as a tool for immunodiagnostic quantification of D-dimer in blood plasma. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：151 / 156
页数：6
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