Dose-response relationship between urinary polycyclic aromatic hydrocarbons metabolites and urinary 8-hydroxy-2'-deoxyguanosine in a Chinese general population

被引：56

作者：

Sun, Huizhen ^{[1
,2
,3
,4
,5
]}

Hou, Jian ^{[1
,2
,3
,4
]}

Zhou, Yun ^{[1
,2
,3
,4
]}

Yang, Yuqing ^{[1
,2
,3
,4
]}

Cheng, Juan ^{[1
,2
,3
,4
]}

Xu, Tian ^{[1
,2
,3
,4
]}

Xiao, Lili ^{[1
,2
,3
,4
]}

Chen, Weihong ^{[1
,2
,3
,4
]}

Yuan, Jing ^{[1
,2
,3
,4
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Occupat & Environm Hlth, Wuhan, Hubei, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Key Lab Environm & Hlth,Minist Educ, Wuhan, Hubei, Peoples R China

[3] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Minist Environm Protect, Wuhan, Hubei, Peoples R China

[4] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, State Key Lab Environm Hlth Incubating, Wuhan, Hubei, Peoples R China

[5] Hubei Ctr Dis Control & Prevent, Wuhan, Hubei, Peoples R China

来源：

CHEMOSPHERE | 2017年 / 174卷

关键词：

Polycyclic aromatic hydrocarbons; BODY-MASS INDEX; OXIDATIVE DNA-DAMAGE; CARDIOVASCULAR-DISEASE; LYMPHOCYTIC MICRONUCLEI; PARTICULATE MATTER; AIR-POLLUTION; ADDUCT LEVELS; RISK-FACTORS; EXPOSURE; STRESS;

D O I：

10.1016/j.chemosphere.2017.01.104

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Association of exposure to polycyclic aromatic hydrocarbons (PAHs) with increased urinary 8-hydroxy2'-deoxyguanosine (8-OHdG) formation has been reported in occupational population and children. However, studies on the association between them in general population are limited. A total of 1864 eligible subjects from the baseline Wuhan participants of the Wuhan-Zhuhai Cohort Study (n = 3053) were included in this study, after excluding individuals with certain disease and missing data on urinary monohydroxy PAHs (OH-PAHs) and 8-OHdG levels. Urinary monohydroxy PAHs and 8-OHdG levels were measured by gas chromatography -mass spectrometry and high performance liquid chromatography electrochemical detection, respectively. Association of urinary OH-PAHs with urinary 8-OHdG was analyzed by multiple linear regression analysis. We found a dose -dependent relationship between urinary PAHs metabolites and urinary 8-OHdG (p < 0.05 for all). Furthermore, more evidence for theassociation of total concentrations of urinary OH-PAHs with 8-OHdG levels were observed in individuals with normal body mass index or central obesity (p < 0.01 for all). There was a dose -dependent relationship between urinary OH-PAHs levels and urinary 8-OHdG levels among a general Chinese population. Exposure to background PAHs may have a greater influence on urinary 8-OHdG levels in individuals with central obesity. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：506 / 514

页数：9

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