An Uncommon Aflibercept Side Effect: Full Thickness Macular Hole Formation After Intravitreal Injections in Patients With Pre-existing Vitreomacular Traction

被引:2
作者
Karamitsos, Athanasios [1 ,2 ]
Sorkou, Konstantina N. [1 ]
Bhagey, Joy [2 ]
Hillier, Roxane J. [2 ]
Papastavrou, Vasileios T. [2 ]
机构
[1] Aristotle Univ Thessaloniki, Dept Ophthalmol 2, Thessaloniki, Greece
[2] Royal Victoria Infirm, Newcastle Eye Dept, Newcastle, NSW, Australia
关键词
aflibercept intravitreal injection; full thickness macular hole; neovascular age-related macular degeneration; pigment epithelial detachment; vitreo-macular traction; RANIBIZUMAB; DETACHMENT;
D O I
10.7759/cureus.12872
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aflibercept is an intravitreally injected anti-vascular endothelial growth factor, commonly used in patients with several retinal pathologies, including neovascular age-related macular degeneration. We report a case series of three patients under treatment with an aflibercept regime for neovascular age-related macular degeneration, who were referred to vitreoretinal service between 2015-2016. In all cases, pre-existing vitreomacular traction was detected with an optical coherence tomography scan. All of them developed fullthickness macular hole after aflibercept intravitreal injections. The combined cataract and macular hole surgery was successful, with improvement in visual acuity. We suggest that dynamic alterations of the size of the pigment epithelium detachment resulting from intravitreal injections might intensify the pre-existing pathological adhesion of the vitreous-retinal interface and subsequently cause the formation of a fullthickness macular hole. Therefore, all practitioners treating patients with aflibercept intravitreal injections and pre-existing vitreomacular traction should be aware of the possible macular hole formation.
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页数:4
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