Protein Kinase D Enzymes as Regulators of EMT and Cancer Cell Invasion

被引：41

作者：

Durand, Nisha ^{[1
]}

Borges, Sahra ^{[1
]}

Storz, Peter ^{[1
]}

机构：

[1] Mayo Clin, Dept Canc Biol, 4500 San Pablo Rd, Jacksonville, FL 32224 USA

来源：

JOURNAL OF CLINICAL MEDICINE | 2016年 / 5卷 / 02期

关键词：

Protein Kinase D; PKD; EMT; migration; cancer; EPITHELIAL-MESENCHYMAL TRANSITION; NF-KAPPA-B; C-MU; PHOSPHORYLATION SITE; D ACTIVATION; GROWTH; EXPRESSION; PKD; DIACYLGLYCEROL; TRANSPORT;

D O I：

10.3390/jcm5020020

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The Protein Kinase D (PKD) isoforms PKD1, PKD2, and PKD3 are effectors of the novel Protein Kinase Cs (nPKCs) and diacylglycerol (DAG). PKDs impact diverse biological processes like protein transport, cell migration, proliferation, epithelial to mesenchymal transition (EMT) and apoptosis. PKDs however, have distinct effects on these functions. While PKD1 blocks EMT and cell migration, PKD2 and PKD3 tend to drive both processes. Given the importance of EMT and cell migration to the initiation and progression of various malignancies, abnormal expression of PKDs has been reported in multiple types of cancers, including breast, pancreatic and prostate cancer. In this review, we discuss how EMT and cell migration are regulated by PKD isoforms and the significance of this regulation in the context of cancer development.

引用

页数：13

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