Organocatalytic Asymmetric Formal [4+2] Cycloaddition for the Synthesis of Spiro[4-cyclohexanone-1,3′-oxindoline] Derivatives in High Optical Purity

被引：222

作者：

Wei, Qiang

Gong, Liu-Zhu ^{[1
]}

机构：

[1] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Peoples R China

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 05期

关键词：

X-RAY-ANALYSIS; ENANTIOSELECTIVE CONSTRUCTION; ALPHA; BETA-UNSATURATED IMIDES; MICHAEL ADDITION; CARBON CENTERS; ALKALOIDS; MARCFORTINE; ENANTIOMER; OXINDOLES; POTENT;

D O I：

10.1021/ol100020v

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A bifunctional organocatalytic asymmetric formal [4 + 2] cycloaddition reaction of Nazarov reagents and methyleneindolinones afforded spiro[4-cyclohexanone-1,3'-oxindoline] derivatives with excellent enantioselectivity (up to 98% ee).

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页码：1008 / 1011

页数：4

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