First report and detailed characterization of B. pertussis isolates not expressing pertussis toxin or pertactin

被引：139

作者：

Bouchez, V. ^{[1
]}

Brun, D. ^{[1
]}

Cantinelli, T. ^{[2
]}

Dore, G. ^{[1
]}

Njamkepo, E. ^{[1
]}

Guiso, N. ^{[1
]}

机构：

[1] CNRS, URA 3012, Unite Prevent & Therapie Mol Malad Humaines, Inst Pasteur, F-75015 Paris, France

[2] Inst Pasteur, Grp Ans Microorganismes & Barrieres Hote 5, Paris, France

来源：

VACCINE | 2009年 / 27卷 / 43期

关键词：

Bordetella pertussis; Pertussis toxin; Pertactin; INTRANASAL MURINE MODEL; BORDETELLA-PERTUSSIS; SEQUENCE VARIATION; ADENYLATE-CYCLASE; VACCINE; INFANTS; BRONCHISEPTICA; PARAPERTUSSIS; POLYMORPHISM; PROTECTION;

D O I：

10.1016/j.vaccine.2009.07.074

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Bordetella pertussis isolates not expressing Pertussis Toxin (PT) or Pertactin (PRN) have been collected, for the first time in 2007, in France, a highly vaccinated country with acellular vaccines. Non-expression was due to deletion of the entire ptx locus, to IS481 insertion in the pm gene or deletion of a part of this gene. Genome sequencing does not indicate any regions of differences when compared to other circulating isolates. It nevertheless shows some sequence differences and an increased number of repeated sequences. The infant infected by the isolate not expressing pertussis toxin, did not present hyperlymphocytosis. All isolates were found less pathogen in animal or cellular models; their circulation raises the problem of clinical and biological diagnoses. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：6034 / 6041

页数：8

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