Cortical-Subcortical Interactions in Depression: From Animal Models to Human Psychopathology

被引：36

作者：

Heller, Aaron S. ^{[1
]}

机构：

[1] Univ Miami, Dept Psychol, POB 248185, Coral Gables, FL 33124 USA

来源：

FRONTIERS IN SYSTEMS NEUROSCIENCE | 2016年 / 10卷

关键词：

depression; emotion; connectivity; animal models of mental disorders; clinical neuroscience; MEDIAL PREFRONTAL CORTEX; DORSAL RAPHE NUCLEUS; MATTER MICROSTRUCTURE ALTERATIONS; ANTERIOR CINGULATE CORTEX; MOOD-REGULATING CIRCUIT; STATE FUNCTIONAL-MRI; WHITE-MATTER; MAJOR DEPRESSION; NEURAL CIRCUITS; TREATMENT-NAIVE;

D O I：

10.3389/fnsys.2016.00020

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Depression is a debilitating disorder causing significant societal and personal suffering. Improvements in identification of major depressive disorder (MDD) and its treatment are essential to reduce its toll. Recent developments in rodent models of MDD and neuroimaging of humans suffering from the disorder provide avenues through which gains can be made towards reducing its burden. In this review, new findings, integrating across rodent models and human imaging are highlighted that have yielded new insights towards a basic understanding of the disorder. In particular, this review focuses on cortical-subcortical interactions underlying the pathophysiology of MDD. In particular, evidence is accruing that dysfunction in prefrontal-subcortical circuits including the amygdala, ventral striatum (VS), hippocampus and dorsal raphe nucleus (DRN) are associated with MDD status.

引用

页数：10

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