Non-acidic cleavage of wang-derived ethers from solid support: Utilization of a mixed-bed scavenger for DDQ

被引：51

作者：

Deegan, TL ^{[1
]}

Gooding, OW ^{[1
]}

Baudart, S ^{[1
]}

Porco, JA ^{[1
]}

机构：

[1] ARGONAUT TECHNOL INC,SAN CARLOS,CA 94070

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 28期

关键词：

D O I：

10.1016/S0040-4039(97)01078-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ethers derived from ArgoGel(R)-Wang-Chloride resin have been prepared and evaluated in both trifluoroacetic acid and DDQ-mediated cleavage protocols. DDQ cleavage of resin-bound p-alkoxy benzyl ethers has been found to circumvent problems associated with trifluoroacetylation of alcohol products during TFA treatment. In order to facilitate the removal of excess DDQ and DDQH from cleaved products, a mixed-bed ion exchange scavenger has been developed. (C) 1997 Elsevier Science Ltd.

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页码：4973 / 4976

页数：4

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