The association between sarcopenia and functional outcomes among older patients with hip fracture undergoing in-hospital rehabilitation

被引:90
作者
Landi, F. [1 ,2 ]
Calvani, R. [1 ]
Ortolani, E. [1 ]
Salini, S. [1 ]
Martone, A. M. [1 ]
Santoro, L. [3 ]
Santoliquido, A. [3 ]
Sisto, A. [1 ]
Picca, A. [1 ]
Marzetti, E. [1 ]
机构
[1] Univ Cattolica Sacro Cuore, Dept Geriatr Neurosci & Orthoped, Rome, Italy
[2] Univ Cattolica Sacro Cuore, Inst Internal Med & Geriatr, Ctr Geriatr Med CEMI, Lgo F Vito 8, I-00168 Rome, Italy
[3] Univ Cattolica Sacro Cuore, Dept Med, Rome, Italy
关键词
Functional recovery; Hip fracture; Rehabilitation program; Sarcopenia; BODY-COMPOSITION; MUSCLE FUNCTION; PREVALENCE; RISK; DEFINITIONS; ADULTS; FALLS; ILSIRENTE; EXERCISE; INDEX;
D O I
10.1007/s00198-017-3929-z
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
This study evaluates the prevalence of sarcopenia among older people admitted to a rehabilitation unit after hip fracture and the association between sarcopenia and functional outcomes. The results show that sarcopenia had a negative impact on functional recovery. The assessment of sarcopenia among older adults receiving rehabilitation programs is crucial. Sarcopenia is a highly prevalent geriatric syndrome associated with adverse outcomes, including falls, disability, institutionalization, and mortality. Few studies assessed sarcopenia among older adults receiving rehabilitation programs. Patients aged 70 years or more consecutively admitted to in-hospital rehabilitation programs that had suffered from hip fracture entered the study. Sarcopenia was defined according to the Foundation for National Institutes of Health (FNIH) criteria. Multivariable linear regression models were used to analyze the association between the sarcopenia and functional recovery. The recruited population was composed of 127 patients, with a mean age of 81.3 +/- 4.8 years, predominantly females (64.6%). Using the criteria proposed by the FNIH, patients with a diagnosis of sarcopenia were 43 (33.9%). After adjustment for potential confounders, participants with sarcopenia had a significant increased risk of incomplete functional recovery compared with non-sarcopenic patients (OR 3.07, 95% CI 1.07-8.75). Compared with participants without sarcopenia, those with sarcopenia showed lower Barthel index scores at the time of discharge from the rehabilitation unit (69.2 versus 58.9, respectively; p < 0.001) and after 3 months of follow-up (90.9 versus 80.5, respectively; p = 0.02). These findings support the systematic assessment of sarcopenia among older adults receiving rehabilitation programs to assist in the development of personalized treatment plans aimed at improving functional outcomes.
引用
收藏
页码:1569 / 1576
页数:8
相关论文
共 33 条
  • [1] Exercise habits during middle age are associated with lower prevalence of sarcopenia: the ROAD study
    Akune, T.
    Muraki, S.
    Oka, H.
    Tanaka, S.
    Kawaguchi, H.
    Nakamura, K.
    Yoshimura, N.
    [J]. OSTEOPOROSIS INTERNATIONAL, 2014, 25 (03) : 1081 - 1088
  • [2] Sarcopenia in daily practice: assessment and management
    Beaudart, Charlotte
    McCloskey, Eugene
    Bruyere, Olivier
    Cesari, Matteo
    Rolland, Yves
    Rizzoli, Rene
    de Carvalho, Islene Araujo
    Thiyagarajan, Jotheeswaran Amuthavalli
    Bautmans, Ivan
    Bertiere, Marie-Claude
    Brandi, Maria Luisa
    Al-Daghri, Nasser M.
    Burlet, Nansa
    Cavalier, Etienne
    Cerreta, Francesca
    Cherubini, Antonio
    Fielding, Roger
    Gielen, Evelien
    Landi, Francesco
    Petermans, Jean
    Reginster, Jean-Yves
    Visser, Marjolein
    Kanis, John
    Cooper, Cyrus
    [J]. BMC GERIATRICS, 2016, 16 : 1 - 10
  • [3] Comparative performance of current definitions of sarcopenia against the prospective incidence of falls among community-dwelling seniors age 65 and older
    Bischoff-Ferrari, H. A.
    Orav, J. E.
    Kanis, J. A.
    Rizzoli, R.
    Schloegl, M.
    Staehelin, H. B.
    Willett, W. C.
    Dawson-Hughes, B.
    [J]. OSTEOPOROSIS INTERNATIONAL, 2015, 26 (12) : 2793 - 2802
  • [4] Effect of vitamin D supplementation alone on muscle function in postmenopausal women: a randomized, double-blind, placebo-controlled clinical trial
    Cangussu, L. M.
    Nahas-Neto, J.
    Orsatti, C. L.
    Bueloni-Dias, F. N.
    Nahas, E. A. P.
    [J]. OSTEOPOROSIS INTERNATIONAL, 2015, 26 (10) : 2413 - 2421
  • [5] Sarcopenia and physical frailty: two sides of the same coin
    Cesari, Matteo
    Landi, Francesco
    Vellas, Bruno
    Bernabei, Roberto
    Marzetti, Emanuele
    [J]. FRONTIERS IN AGING NEUROSCIENCE, 2014, 6
  • [6] Definitions of Sarcopenia: Associations with Previous Falls and Fracture in a Population Sample
    Clynes, M. A.
    Edwards, M. H.
    Buehring, B.
    Dennison, E. M.
    Binkley, N.
    Cooper, C.
    [J]. CALCIFIED TISSUE INTERNATIONAL, 2015, 97 (05) : 445 - 452
  • [7] Prevalence of and interventions for sarcopenia in ageing adults: a systematic review. Report of the International Sarcopenia Initiative (EWGSOP and IWGS)
    Cruz-Jentoft, Alfonso J.
    Landi, Francesco
    Schneider, Stephane M.
    Zuniga, Clemente
    Arai, Hidenori
    Boirie, Yves
    Chen, Liang-Kung
    Fielding, Roger A.
    Martin, Finbarr C.
    Michel, Jean-Pierre
    Sieber, Cornel
    Stout, Jeffrey R.
    Studenski, Stephanie A.
    Vellas, Bruno
    Woo, Jean
    Zamboni, Mauro
    Cederholm, Tommy
    [J]. AGE AND AGEING, 2014, 43 (06) : 748 - 759
  • [8] Sarcopenia: European consensus on definition and diagnosis
    Cruz-Jentoft, Alfonso J.
    Baeyens, Jean Pierre
    Bauer, Juergen M.
    Boirie, Yves
    Cederholm, Tommy
    Landi, Francesco
    Martin, Finbarr C.
    Michel, Jean-Pierre
    Rolland, Yves
    Schneider, Stephane M.
    Topinkova, Eva
    Vandewoude, Maurits
    Zamboni, Mauro
    [J]. AGE AND AGEING, 2010, 39 (04) : 412 - 423
  • [9] Understanding sarcopenia as a geriatric syndrome
    Cruz-Jentoft, Alfonso J.
    Landi, Francesco
    Topinkova, Eva
    Michel, Jean-Pierre
    [J]. CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE, 2010, 13 (01) : 1 - 7
  • [10] Considerations concerning the definition of sarcopenia
    Dawson-Hughes, B.
    Bischoff-Ferrari, H.
    [J]. OSTEOPOROSIS INTERNATIONAL, 2016, 27 (11) : 3139 - 3144