Allogeneic stem cell transplantation as a curative option in relapse/refractory diffuse large B cell lymphoma: Spanish multicenter GETH/GELTAMO study

被引：21

作者：

Bento, Leyre ^{[1
]}

Gutierrez, Antonio ^{[1
]}

Novelli, Silvana ^{[2
]}

Montoro, Juan ^{[3
]}

Pinana, J. L. ^{[3
]}

Lopez-Corral, Lucia ^{[4
]}

Cabrero, Monica ^{[4
]}

Martin-Sancho, Alejandro ^{[4
]}

Gutierrez-Garcia, Gonzalo ^{[5
]}

Ortiz-Moscovich, Marcela ^{[5
]}

Bastos-Oreiro, Mariana ^{[6
]}

Dorado, Nieves ^{[6
]}

Perez, Ariadna ^{[7
]}

Hernani, Rafael ^{[7
]}

Ferra, Christelle ^{[8
]}

Parody, Rocio ^{[9
]}

Garcia-Cadenas, Irene ^{[2
]}

Herrera, Pilar ^{[10
]}

Rodriguez, Guillermo ^{[11
]}

Rodriguez, Nancy ^{[11
]}

Martin, Carmen ^{[12
]}

Yanez, Lucrecia ^{[13
]}

Zanabili, Joud ^{[14
]}

Varela, Maria Rosario ^{[15
]}

Lopez-Godino, Oriana ^{[16
]}

Heras, Inmaculada ^{[16
]}

Espanol, Ignacio ^{[17
]}

Martinez, Carmen ^{[5
]}

Perez-Simon, Jose Antonio ^{[11
]}

Solano, Carlos

Sureda, Anna

Sierra, Jordi ^{[2
]}

Sampol, Antonia ^{[1
]}

Caballero, Dolores ^{[4
]}

机构：

[1] IdISBa, Son Espases Univ Hosp, Palma De Mallorca, Spain

[2] Hosp Santa Creu & Sant Pau, Barcelona, Spain

[3] Hosp La Fe, Valencia, Spain

[4] Hosp Univ Salamanca, Salamanca, Spain

[5] Hosp Clin Barcelona, Barcelona, Spain

[6] Hosp Gen Univ Gregorio Maranon, Madrid, Spain

[7] Hosp Clin Valencia, Valencia, Spain

[8] ICO IJC Hosp Germans Trias & Pujol, Badalona, Spain

[9] Inst Catala Oncol ICO, Lhospitalet De Llobregat, Spain

[10] Hosp Ramon & Cajal, Madrid, Spain

[11] Univ Seville, Hosp Virgen Rocio, Inst Biomed Sevilla, IBIS,CSIC,CIBERONC, Seville, Spain

[12] Hosp Reina Sofia, Cordoba, Spain

[13] Hosp Valdecilla, Santander, Spain

[14] Hosp Asturias, Oviedo, Spain

[15] Hosp Juan Canalejo, Coruna, Spain

[16] Hosp Morales Meseguer, Murcia, Spain

[17] Hosp Univ Virgen Arrixaca, Murcia, Spain

来源：

BONE MARROW TRANSPLANTATION | 2021年 / 56卷 / 08期

关键词：

D O I：

10.1038/s41409-021-01264-3

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

We performed a retrospective multicenter study including 140 patients with relapsed/refractory (R/R) diffuse large B cell lymphoma (DLBCL) who underwent allogeneic hematopoietic stem cell transplantation (allo-SCT) from March 1995 to November 2018. Our objective was to analyze long term outcomes. Seventy-four percent had received a previous auto-SCT (ASCT) and the median number of lines pre-allo-SCT was 3 (range 1-9). Three year-event free survival (EFS) and overall survival (OS) were 38% and 44%, respectively. Non-relapse mortality (NRM) at day 100 was 19%. Cumulative incidence of grade III-IV acute graft versus host disease (GVHD) at day 100 was 16% and moderate/severe chronic GVHD at 3 years 34%. Active disease at allo-SCT (HR 1.95, p = 0.039) (HR 2.19, p = 0.019), HCT-CI >= 2 (2.45, p = 0.002) (HR 2.33, p = 0.006) and donor age >37 years (HR 2.75, p = 0.014) (HR 1.98, p = 0.043) were the only independent variables both for PFS and OS, respectively. NRM was significantly modified by HCT-CI >= 2 (HR 4.8, p = 0.008), previous ASCT (HR 4.4, p = 0.048) and grade III-IV acute GVHD on day 100 (HR 6.13, p = 0.016). Our data confirmed that allo-SCT is a curative option for patients with R/R DLBCL, displaying adequate results for fit patients with chemosensitive disease receiving an allo-SCT from a young donor.

引用

页码：1919 / 1928

页数：10

共 34 条

[1] A disease risk index for patients undergoing allogeneic stem cell transplantation [J].

Armand, Philippe ;

Gibson, Christopher J. ;

Cutler, Corey ;

Ho, Vincent T. ;

Koreth, John ;

Alyea, Edwin P. ;

Ritz, Jerome ;

Sorror, Mohamed L. ;

Lee, Stephanie J. ;

Deeg, H. Joachim ;

Storer, Barry E. ;

Appelbaum, Frederick R. ;

Antin, Joseph H. ;

Soiffer, Robert J. ;

Kim, Haesook T. .

BLOOD, 2012, 120 (04) :905-913

[2] Matched unrelated donor allogeneic transplantation provides comparable long-term outcome to HLA-identical sibling transplantation in relapsed diffuse large B-cell lymphoma [J].

Avivi, I. ;

Canals, C. ;

Vernant, J-P ;

Wulf, G. ;

Nagler, A. ;

Hermine, O. ;

Petersen, E. ;

Yakoub-Agha, I. ;

Craddock, C. ;

Schattenberg, A. ;

Niederwieser, D. ;

Thomson, K. ;

Blaise, D. ;

Attal, M. ;

Pfreundschuh, M. ;

Passweg, J. ;

Russell, N. ;

Dreger, P. ;

Sureda, A. .

BONE MARROW TRANSPLANTATION, 2014, 49 (05) :671-678

[3] Conditioning regimens for allotransplants for diffuse large B-cell lymphoma: myeloablative or reduced intensity? [J].

Bacher, Ulrike ;

Klyuchnikov, Evgeny ;

Le-Rademacher, Jennifer ;

Carreras, Jeanette ;

Armand, Philippe ;

Bishop, Michael R. ;

Bredeson, Christopher N. ;

Cairo, Mitchell S. ;

Fenske, Timothy S. ;

Freytes, Cesar O. ;

Gale, Robert Peter ;

Gibson, John ;

Isola, Luis M. ;

Inwards, David J. ;

Laport, Ginna G. ;

Lazarus, Hillard M. ;

Maziarz, Richard T. ;

Wiernik, Peter H. ;

Schouten, Harry C. ;

Slavin, Shimon ;

Smith, Sonali M. ;

Vose, Julie M. ;

Waller, Edmund K. ;

Hari, Parameswaran N. .

BLOOD, 2012, 120 (20) :4256-4262

[4] Defining the Intensity of Conditioning Regimens: Working Definitions [J].

Bacigalupo, Andrea ;

Ballen, Karen ;

Rizzo, Doug ;

Giralt, Sergio ;

Lazarus, Hillard ;

Ho, Vincent ;

Apperley, Jane ;

Slavin, Shimon ;

Pasquini, Marcelo ;

Sandmaier, Brenda M. ;

Barrett, John ;

Blaise, Didier ;

Lowski, Robert ;

Horowitz, Mary .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2009, 15 (12) :1628-1633

[5] Revised response criteria for malignant lymphoma [J].

Cheson, Bruce D. ;

Pfistner, Beate ;

Juweid, Malik E. ;

Gascoyne, Randy D. ;

Specht, Lena ;

Horning, Sandra J. ;

Coiffier, Bertrand ;

Fisher, Richard I. ;

Hagenbeek, Anton ;

Zucca, Emanuele ;

Rosen, Steven T. ;

Stroobants, Sigrid ;

Lister, T. Andrew ;

Hoppe, Richard T. ;

Dreyling, Martin ;

Tobinai, Kensei ;

Vose, Julie M. ;

Connors, Joseph M. ;

Federico, Massimo ;

Diehl, Volker .

JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (05) :579-586

[6] Recommendations for Initial Evaluation, Staging, and Response Assessment of Hodgkin and Non-Hodgkin Lymphoma: The Lugano Classification [J].

Cheson, Bruce D. ;

Fisher, Richard I. ;

Barrington, Sally F. ;

Cavalli, Franco ;

Schwartz, Lawrence H. ;

Zucca, Emanuele ;

Lister, T. Andrew .

JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (27) :3059-+

[7] Outcomes in refractory diffuse large B-cell lymphoma: results from the international SCHOLAR-1 study [J].

Crump, Michael ;

Neelapu, Sattva S. ;

Farooq, Umar ;

Van den Neste, Eric ;

Kuruvilla, John ;

Westin, Jason ;

Link, Brian K. ;

Hay, Annette ;

Cerhan, James R. ;

Zhu, Liting ;

Boussetta, Sami ;

Feng, Lei ;

Maurer, Matthew J. ;

Navale, Lynn ;

Wiezorek, Jeff ;

Go, William Y. ;

Gisselbrecht, Christian .

BLOOD, 2017, 130 (16) :1800-1808

[8] Cellular Immunotherapy for Refractory Diffuse Large B Cell Lymphoma in the Chimeric Antigen Receptor-Engineered T Cell Era: Still a Role for Allogeneic Transplantation? [J].

Dreger, Peter ;

Fenske, Timothy S. ;

Montoto, Silvia ;

Pasquini, Marcelo C. ;

Sureda, Anna ;

Hamadani, Mehdi .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2020, 26 (04) :E77-E85

[9] PTCy-based haploidentical vs matched related or unrelated donor reduced-intensity conditioning transplant for DLBCL [J].

Dreger, Peter ;

Sureda, Anna ;

Ahn, Kwang Woo ;

Eapen, Mary ;

Litovich, Carlos ;

Finel, Herve ;

Boumendil, Ariane ;

Gopal, Ajay ;

Herrera, Alex F. ;

Schmid, Christoph ;

Diez-Martin, Jose Luis ;

Fuchs, Ephraim ;

Bolanos-Meade, Javier ;

Gooptu, Mahasweta ;

Al Malki, Monzr M. ;

Castagna, Luca ;

Ciurea, Stefan O. ;

Dominietto, Alida ;

Blaise, Didier ;

Ciceri, Fabio ;

Tischer, Johanna ;

Corradini, Paolo ;

Montoto, Silvia ;

Robinson, Stephen ;

Gulbas, Zafer ;

Hamadani, Mehdi .

BLOOD ADVANCES, 2019, 3 (03) :360-369

[10] The hematopoietic cell transplantation comorbidity index (HCT-CI) predicts clinical outcomes in lymphoma and myeloma patients after reduced-intensity or non-myeloablative allogeneic stem cell transplantation [J].

Farina, L. ;

Bruno, B. ;

Patriarca, F. ;

Spina, F. ;

Sorasio, R. ;

Morelli, M. ;

Fanin, R. ;

Boccadoro, M. ;

Corradini, P. .

LEUKEMIA, 2009, 23 (06) :1131-1138

← 1 2 3 4 →