Dose volume effects of re-irradiation for locally recurrent nasopharyngeal carcinoma

被引：12
作者：
Ng, Wai-Tong [1 ]
Lee, Michael C. H. [2 ]
Fung, Nelson T. C. [2 ]
Wong, Edwin C. Y. [1 ]
Cheung, Alice K. W. [3 ]
Chow, James C. H. [4 ]
Au, Kwok-Hung [4 ]
Poon, Darren M. C. [5 ]
Lai, Jessica W. Y. [6 ]
Chiang, Chi-Leung [7 ]
Choi, Horace C. W. [7 ]
Chau, Tin-Ching [7 ]
Lee, Victor H. F. [7 ]
Lee, Anne W. M. [7 ]
机构：
[1] Pamela Youde Nethersole Eastern Hosp, Dept Clin Oncol, Hong Kong, Peoples R China
[2] Pamela Youde Nethersole Eastern Hosp, Dept Med Phys, Hong Kong, Peoples R China
[3] Tuen Mun Hosp, Dept Clin Oncol, Hong Kong, Peoples R China
[4] Queen Elizabeth Hosp, Dept Clin Oncol, Hong Kong, Peoples R China
[5] Prince Wales Hosp, Dept Clin Oncol, Hong Kong, Peoples R China
[6] Princess Margaret Hosp, Dept Clin Oncol, Hong Kong, Peoples R China
[7] Univ Hong Kong, Dept Clin Oncol, Li Ka Shing Faulty Med, Hong Kong, Peoples R China
来源：
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2020年 / 42卷 / 02期
关键词：
local recurrence; nasopharyngeal carcinoma; re-irradiation; salvage; toxicities; INTENSITY-MODULATED RADIOTHERAPY; LONG-TERM OUTCOMES; PROGNOSTIC-FACTORS; RADIATION-THERAPY; SURVIVAL; SALVAGE; PHASE-2; MODEL;
D O I：
10.1002/hed.25988
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Background This study analyzed the dose volume effects of re-irradiation for locally recurrent nasopharyngeal carcinoma (NPC) and attempts to determine the optimal dose for the best survival. Methods Ninety-one patients were studied. The local control, fatal complication, and overall survival were analyzed against the dose (in Equivalent Dose at 2 Gy/fractions) and recurrent gross tumor volume (GTV). Results The local control and fatal complication rate appear to increase with prescribed dose. The overall survival peaks at around 60 Gy(10). Local control decreases significantly with increasing GTV (P < .001) while overall survival shows similar trend (P = .06). No correlation was observed between the fatal complication rate and GTV volume. The dose response of local control appears to be stronger for smaller tumors. Conclusion GTV volume plays a significant role in local control. A 60 Gy(10) appears to be optimal for the best survival outcome; higher doses might be considered for small tumors.
引用
收藏
页码：180 / 187
页数：8
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