Low levels of co-receptor CCR5 are sufficient to permit HIV envelope-mediated fusion with resting CD4 T cells

被引：16

作者：

Chanel, C

Staropoli, I

Baleux, F

Amara, A

Valenzuela-Fernandez, A

Virelizier, JL

Arenzana-Seisdedos, F

Altmeyer, R

机构：

[1] Inst Pasteur, Unite Immunol Virale, F-75015 Paris, France

[2] Inst Pasteur, Unite Chim Organ, F-75015 Paris, France

来源：

AIDS | 2002年 / 16卷 / 17期

关键词：

D O I：

10.1097/00002030-200211220-00016

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The susceptibility of phenotypically CCR3-negative resting CD4 T cells for membrane fusion with a CCR5-specific HIV-1 envelope was analysed using a novel sensitive fusion assay. A very low overall density of CCR5 on T cells expressing high levels of CD4 was shown to be sufficient for HIV envelope-mediated membrane fusion. These findings are relevant to the understanding of how HIV-1 R5 strains enter and replicate in resting CD4 T cells in vivo.

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页码：2337 / 2340

页数：4

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