Sleep Apnea is an Independent Correlate of Erectile and Sexual Dysfunction

被引:102
作者
Budweiser, Stephan [1 ]
Enderlein, Stefan [1 ]
Joerres, Rudolf A. [2 ]
Hitzl, Andre P. [1 ]
Wieland, Wolf F. [3 ]
Pfeifer, Michael [1 ,4 ]
Arzt, Michael [4 ]
机构
[1] Donaustauf Hosp, Ctr Pneumol, D-93093 Donaustauf, Germany
[2] Univ Munich, Inst & Outpatient Clin Occupat Social & Environm, Munich, Germany
[3] Univ Regensburg, St Joseph Hosp, Dept Urol, Regensburg, Germany
[4] Univ Regensburg, Div Respirol, Dept Internal Med 2, Regensburg, Germany
关键词
Obstructive Sleep Apnea-Hypopnea Syndrome; Sexual Function; Risk Factors; Oxidative Stress; Sleep Apnea; Endothelial Dysfunction; POSITIVE AIRWAY PRESSURE; NOCTURNAL PENILE TUMESCENCE; ENDOTHELIAL FUNCTION; INTERNATIONAL INDEX; RESISTANCE VESSELS; OXIDATIVE STRESS; CPAP TREATMENT; NITRIC-OXIDE; RISK-FACTOR; MEN;
D O I
10.1111/j.1743-6109.2009.01372.x
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Introduction. Obstructive sleep apnea (OSA) has been linked with erectile dysfunction (ED), but it is unknown whether this association is maintained in the presence of other risk factors for ED. Aim. The aim of this study was to evaluate the relationship between ED/sexual dysfunction and polysomnographic measures of sleep apnea in patients with known risk factors for ED. Methods. Prospective cross-sectional analysis of 401 male patients undergoing in-lab polysomnography for suspected OSA. Erectile (EF) and sexual function were assessed by the 15-item International Index of Erectile Function (IIEF-15) questionnaire. Main Outcome Measures. Severity of OSA via apnea-hypopnea index (AHI) and mean/lowest nocturnal oxygen saturation (SaO(2)). The IIEF-15 including the sexual domains: EF, intercourse satisfaction, orgasmic function, sexual desire, and overall satisfaction. Results. OSA (AHI > 5/h) was diagnosed in 92% of patients. ED (EF subdomain < 25) was present in 69% of patients with, and 34% of patients without OSA (P < 0.001). Multivariate stepwise regression analyses including known risk factors for ED, such as age, obesity, coronary heart disease, peripheral occlusive disease, hypertension, diabetes, prostate surgery, and beta-blocker treatment, and measures of sleep apnea identified mean nocturnal SaO(2) as independently associated with ED (P = 0.002; mean [95% CI] normalized slope 0.126 [0.047; 0.205]). Age (P < 0.001), peripheral occlusive disease (P = 0.001), prostate surgery (P = 0.018), and hypertension (P = 0.021) were confirmed as risk factors for ED, but did not abolish the sleep apnea-associated risk. Similar results were obtained for sexual dysfunction. Logistic regression analysis using the diagnosis of ED (EF subdomain < 25) as binary dependent variable confirmed that mean nocturnal SaO(2) (P = 0.012), as well as age (P < 0.001) were independently associated with ED. Conclusions. ED and overall sexual dysfunction were highly prevalent in patients with suspected OSA. Irrespective of known risk factors, mean nocturnal SaO(2) was an additional, independent correlate of these dysfunctions, suggesting that OSA-related intermittent nocturnal hypoxemia specifically contributes to their development. Budweiser S, Enderlein S, Jorres RA, Hitzl AP, Wieland WF, Pfeifer M, and Arzt M. Sleep apnea is an independent correlate of erectile and sexual dysfunction. J Sex Med 2009;6:3147-3157.
引用
收藏
页码:3147 / 3157
页数:11
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