Rimegepant Calcitonin gene-related peptide (CGRP) receptor antagonist Treatment of migraine

被引：6

作者：

Lionetto, L. ^{[1
]}

Capi, M. ^{[1
]}

Curto, M. ^{[2
,3
]}

Cipolla, F. ^{[4
]}

Guglielmetti, M. ^{[4
,5
]}

Martelletti, P. ^{[4
,5
,6
]}

机构：

[1] St Andrea Univ Hosp, Mass Spectrometry Lab, Clin Biochem Lab, Rome, Italy

[2] Sapienza Univ Rome, Dept Human Neurosci, Rome, Italy

[3] ASL Roma 5, Dept Mental Hlth, Colleferro, RM, Italy

[4] Sapienza Univ Rome, Dept Clin & Mol Med, Rome, Italy

[5] Univ Sassari, Sassari, Italy

[6] St Andrea Hosp, Reg Referral Headache Ctr, Rome, Italy

来源：

DRUGS OF THE FUTURE | 2019年 / 44卷 / 08期

关键词：

Rimegepant; BHV-3000; BMS-927711; Migraine; CGRP; CGRP receptor antagonist; Gepants; BMS-927711; DISEASE; BURDEN;

D O I：

10.1358/dof.2019.44.8.3024184

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Rimegepant is an oral calcitonin gene-related peptide (CGRP) receptor antagonist and is currently under development by Biohaven Pharmaceuticals for the acute and preventive treatment of migraine. Among patients with acute migraine, significant clinical efficacy has been reported with a rimegepant single dose. The completed pivotal phase II and III trials showed a beneficial action of rimegepant in terms of pain freedom, pain relief, release of migraine symptoms and lifestyle recovery. Moreover, adverse events were mild or moderate and did not cause trial discontinuation. Several clinical trials are currently ongoing to evaluate long-term safety and efficacy profiles in patients with migraine and refractory trigeminal neuralgia. Drug-drug interactions potentially affecting rimegepant pharmacokinetics should be assessed in future clinical trials.

引用

页码：635 / 642

页数：8

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