Cannabinoid Poisoning by Hemp Seed Oil in a Child

被引:16
作者
Chinello, Matteo [1 ]
Scommegna, Salvatore [2 ]
Shardlow, Alison [1 ]
Mazzoli, Francesca [2 ]
De Giovanni, Nadia [3 ]
Fucci, Nadia [3 ]
Borgiani, Paola [4 ]
Ciccacci, Cinzia [4 ]
Locasciulli, Anna [2 ]
Calvani, Mauro [2 ]
机构
[1] Univ Trieste, Inst Maternal & Child Hlth, IRCCS Burlo Garofolo, Trieste, Italy
[2] S Camillo Forlanini Hosp, Dept Pediat & Pediat Hematol, Rome, Italy
[3] Univ Cattolica Sacro Cuore, Publ Hlth Inst, Legal Med Dept, Milan, Italy
[4] Univ Roma Tor Vergata, Genet Unit, Dept Biomed & Prevent, Rome, Italy
关键词
poisoning; hemp seed oil; unconventional medicine; cannabinoid; Delta(9)-tetrahydrocannabinol; CYP2C9; CYP3A4;
D O I
10.1097/PEC.0000000000000780
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
We report a case of mild cannabinoid poisoning in a preschool child, after 3-week ingestion of hemp seed oil prescribed by his pediatrician to strengthen his immune system. The patient presented neurological symptoms that disappeared after intravenous hydration. A possible mild withdrawal syndrome was reported after discharge. The main metabolite of Delta(9)-tetrahydrocannabinol was detected in urine, and very low concentration of Delta(9)-tetrahydrocannabinol was detected in the ingested product. This is, as far as we know, the first report of cannabinoid poisoning after medical prescription of hemp seed oil in a preschool child.
引用
收藏
页码:344 / 345
页数:2
相关论文
共 10 条
[1]   Cannabis cookies: A cause of coma [J].
Boros, CA ;
Parsons, DW ;
Zoanetti, GD ;
Ketteridge, D ;
Kennedy, D .
JOURNAL OF PAEDIATRICS AND CHILD HEALTH, 1996, 32 (02) :194-195
[2]   Efficacy of dietary hempseed oil in patients with atopic dermatitis [J].
Callaway, J ;
Schwab, U ;
Harvima, I ;
Halonen, P ;
Mykkänen, O ;
Hyvönen, P ;
Järvinen, T .
JOURNAL OF DERMATOLOGICAL TREATMENT, 2005, 16 (02) :87-94
[3]   Hemp oil ingestion causes positive urine tests for Delta(9)-tetrahydrocannabinol carboxylic acid [J].
Costantino, A ;
Schwartz, RH ;
Kaplan, P .
JOURNAL OF ANALYTICAL TOXICOLOGY, 1997, 21 (06) :482-485
[4]   Δ9-tetrahydrocannabinol content of commercially available hemp products [J].
Holler, Justin M. ;
Bosy, Thomas Z. ;
Dunkley, Christopher S. ;
Levine, Barry ;
Past, Marilyn R. ;
Jacobs, Aaron .
JOURNAL OF ANALYTICAL TOXICOLOGY, 2008, 32 (06) :428-432
[5]   A comparison of fish oil, flaxseed oil and hempseed oil supplementation on selected parameters of cardiovascular health in healthy volunteers [J].
Kaul, Nalini ;
Kreml, Renee ;
Austria, J. Alejandro ;
Richard, Melanie N. ;
Edel, Andrea L. ;
Dibrov, Elena ;
Hirono, Satoru ;
Zettler, Marjorie E. ;
Pierce, Grant N. .
JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION, 2008, 27 (01) :51-58
[6]   Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother [J].
Koren, Gideon ;
Cairns, James ;
Chitayak, David ;
Gaedigk, Andrea ;
Leeder, Steven J. .
LANCET, 2006, 368 (9536) :704-704
[7]  
MACNAB A, 1989, Pediatric Emergency Care, V5, P238, DOI 10.1097/00006565-198912000-00010
[8]  
Meier H, 1997, SCHWEIZ MED WSCHR, V127, P214
[9]   Cholesterol-induced stimulation of platelet aggregation is prevented by a hempseed-enriched diet [J].
Prociuk, M. A. ;
Edel, A. L. ;
Richard, M. N. ;
Gavel, N. T. ;
Ander, B. P. ;
Dupasquier, C. M. C. ;
Pierce, G. N. .
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2008, 86 (04) :153-159
[10]   Clinical relevance of genetic polymorphisms in the human CYP2C9 gene [J].
Schwarz, UI .
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2003, 33 :23-30