Association between new-onset liver cirrhosis and suicide risk in South Korea: A nationwide cohort study

被引:12
作者
Jang, Suk-Yong [1 ,4 ]
Rou, Woo Sun [2 ,3 ,5 ]
Kim, Seok Hyun [2 ,3 ]
Lee, Byung Seok [2 ,3 ]
Eun, Hyuk Soo [2 ,3 ]
机构
[1] Eulji Univ, Dept Prevent Med, Coll Med, Daejeon, South Korea
[2] Chungnam Natl Univ, Dept Internal Med, Sch Med, 266 Munhwa Ro, Daejeon 35015, South Korea
[3] Chungnam Natl Univ Hosp, Dept Internal Med, Daejeon, South Korea
[4] Yonsei Univ, Grad Sch Publ Hlth, Dept Healthcare Management, Seoul, South Korea
[5] Chungnam Natl Univ, Dept Internal Med, Sejong Hosp, Sejong, South Korea
关键词
Liver cirrhosis; Suicide; Risk; Depression; Psychological distress; DEPRESSION; DISEASE;
D O I
10.3350/cmh.2020.0227
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background/Aims: Current evidence suggests that liver cirrhosis (LC) causes severe psychological stress and depression, which are risk factors for suicide. Although previous studies reported the association between LC and suicidal thoughts, little is known of its effect on suicidal deaths. Therefore, this study was undertaken to investigate the effect of new-onset LC on suicide. Methods: From the National Health Insurance Service-National Sample Cohort of South Korea, 5,809 incident LC patients and 11,618 risk-set controls matched by propensity score were selected for follow-up. The incidence rate of suicide was estimated using a generalized estimating equation with a Poisson distribution. Effect size was presented as a hazard ratio (HR) using Cox's proportional hazards model. Results: The incidence rate of suicide was 143.3 cases per 100,000 person years (95% confidence interval [CI], 100.2-205.1) among the LC cohort. The LC patients were 2.37 times more likely to commit suicide compared with matched controls (HR, 2.37; 95% CI, 1.44-3.88). Increased suicide risk was evident within the first 2 years of the follow-up period (HR, 2.59; 95% CI, 1.20-5.60) and among the 18-49-year-old age group (HR, 3.72; 95% CI, 1.45-9.56). Conclusions: Our study found increased risk of suicide in patients with new onset LC, especially during the early period following diagnosis and in younger patients. To decrease this suicide risk, a regular and continuous social support system is required.
引用
收藏
页码:283 / 294
页数:12
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