Differential-pulse polarography determination of pipamperone in pharmaceutical formulations

被引：6
作者：
Belgaied, JE
Trabelsi, H
机构：
[1] Inst Natl Sci Appl & Technol, Tunis 1080, Tunisia
[2] IAB Pharma, Tunis 2035, Tunisia
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2002年 / 30卷 / 04期
关键词：
pipamperone; butyrophenone; DPP; pharmaceutical formulation;
D O I：
10.1016/S0731-7085(02)00452-1
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The electrochemical reduction of pipamperone has been carried out in aqueous solution in KNO3 (0.1 mol l(-1)) by differential-pulse polarography (DPP). Pipamperone exhibits a well-defined irreversible reduction peak at - 1.3 V/ref. The influence of pH on the reduction of pipamperone was studied in Britton-Robinson buffer (pH range 2-10). A method for the analysis of pipamperone in KNO3 (0.1 mol l(-1)), which allows quantification over the range 1.6 x 10(-5)-2.0 x 10(-4) mol l(-1), was proposed and successfully applied to the determination of pipamperone in tablets with mean recovery and relative standard deviation (R.S.D.) of 100.35 and 0.49%, respectively. (C) 2002 Elsevier Science B.V. All rights reserved.
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收藏
页码：1417 / 1423
页数：7
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