Differential-pulse polarography determination of pipamperone in pharmaceutical formulations

被引：6

作者：

Belgaied, JE

Trabelsi, H

机构：

[1] Inst Natl Sci Appl & Technol, Tunis 1080, Tunisia

[2] IAB Pharma, Tunis 2035, Tunisia

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2002年 / 30卷 / 04期

关键词：

pipamperone; butyrophenone; DPP; pharmaceutical formulation;

D O I：

10.1016/S0731-7085(02)00452-1

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The electrochemical reduction of pipamperone has been carried out in aqueous solution in KNO3 (0.1 mol l(-1)) by differential-pulse polarography (DPP). Pipamperone exhibits a well-defined irreversible reduction peak at - 1.3 V/ref. The influence of pH on the reduction of pipamperone was studied in Britton-Robinson buffer (pH range 2-10). A method for the analysis of pipamperone in KNO3 (0.1 mol l(-1)), which allows quantification over the range 1.6 x 10(-5)-2.0 x 10(-4) mol l(-1), was proposed and successfully applied to the determination of pipamperone in tablets with mean recovery and relative standard deviation (R.S.D.) of 100.35 and 0.49%, respectively. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：1417 / 1423

页数：7

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