The effects of PGD2 and DK-PGD2 on features of airway remodeling in human airway epithelial cells and guinea pig lung slices

被引:0
|
作者
Rahmawati, Siti Farah [1 ]
Verschut, Vassiliki [2 ]
Woest, Manon [2 ]
Kerstjens, Huib [3 ]
Sandham, David [4 ]
Gosens, Reinoud [1 ]
Kistemaker, Loes [2 ]
机构
[1] Univ Groningen, Dept Mol Pharmacol, Groningen, Netherlands
[2] Aquilo, Groningen, Netherlands
[3] Univ Med Ctr Groningen UMCG, Dept Pulm Med, Groningen, Netherlands
[4] Novartis Inst Biomed Res, Horsham, W Sussex, England
关键词
Asthma; Pharmacology; Experimental approaches;
D O I
10.1183/13993003.congress-2020.1418
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
1418
引用
收藏
页数:2
相关论文
共 41 条
  • [1] COX-1 driven biosynthesis of PGD2 during activation of human mast cells prevents formation of other prostanoids
    Johnsson, AnnaKarin
    Choi, Jeong-Hee
    Ronnberg, Elin
    Fuchs, David
    Kolmert, Johan
    Hamberg, Mats
    Dahlen, Barbro
    Wheelock, Craig E.
    Dahlen, Sven-Erik
    Nilsson, Gunnar
    EUROPEAN RESPIRATORY JOURNAL, 2020, 56
  • [2] The Roles of Type 2 Cytotoxic T Cells in Inflammation, Tissue Remodeling, and Prostaglandin (PG) D2 Production Are Attenuated by PGD2 Receptor 2 Antagonism
    Chen, Wentao
    Luo, Jian
    Ye, Yuan
    Hoyle, Ryan
    Liu, Wei
    Borst, Rowie
    Kazani, Shamsah
    Shikatani, Eric A.
    Erpenbeck, Veit J.
    Pavord, Ian D.
    Klenerman, Paul
    Sandham, David A.
    Xue, Luzheng
    JOURNAL OF IMMUNOLOGY, 2021, 206 (11) : 2714 - 2724
  • [3] Identification of helicobacter pylori VacA in human lung and its effects on airway epithelial cells
    Nakashima, Shota
    Kakugawa, Tomoyuki
    Harada, Tatsuhiko
    Hara, Shintaro
    Sakamoto, Noriho
    Nakano, Masayuki
    Ishimatsu, Yuji
    Isomoto, Hajime
    Mukae, Hiroshi
    Kurazono, Hisao
    Hirayama, Toshiya
    Kohno, Shigeru
    EUROPEAN RESPIRATORY JOURNAL, 2013, 42
  • [4] Human airway epithelial cells express interleukin-2 in vitro
    Aoki, Y
    Diu, DM
    Uyei, A
    Kao, PN
    AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 1997, 272 (02) : L276 - L286
  • [5] Regulation of TLR2 Expression and Function in Human Airway Epithelial Cells
    Melkamu, Tamene
    Squillace, Diane
    Kita, Hirohito
    O'Grady, Scott M.
    JOURNAL OF MEMBRANE BIOLOGY, 2009, 229 (02) : 101 - 113
  • [6] Effects of a Cysteinyl Leukotriene Dual 1/2 Receptor Antagonist on Antigen-Induced Airway Hypersensitivity and Airway Inflammation in a Guinea Pig Asthma Model
    Muraki, Masato
    Imbe, Shu
    Santo, Hiroshi
    Sato, Ryuji
    Sano, Hiroyuki
    Iwanaga, Takashi
    Tohda, Yuji
    INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2011, 155 : 90 - 95
  • [7] Functional Expression of γ-Amino Butyric Acid Transporter 2 in Human and Guinea Pig Airway Epithelium and Smooth Muscle
    Zaidi, Sarah
    Gallos, George
    Yim, Peter D.
    Xu, Dingbang
    Sonett, Joshua R.
    Panettieri, Reynold A., Jr.
    Gerthoffer, William
    Emala, Charles W.
    AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2011, 45 (02) : 332 - 339
  • [8] Effects of Th-2 type cytokines on human airway epithelial cells: Interleukins-4,-5, and-13
    Relova, AJ
    Kampf, C
    Roomans, GM
    CELL BIOLOGY INTERNATIONAL, 2001, 25 (06) : 563 - 566
  • [9] Calcium entry is regulated by Zn2+ in relation to extracellular ionic environment in human airway epithelial cells
    Hargitai, Dora
    Pataki, Agnes
    Raffai, Gabor
    Fuezi, Marta
    Danko, Tamas
    Csernoch, Laszlo
    Varnai, Peter
    Szigeti, Gyula Peter
    Zsembery, Akos
    RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, 2010, 170 (01) : 67 - 75
  • [10] EFFECTS OF BETA(2)-ADRENERGIC AGONISTS ON ISOLATED GUINEA-PIG LUNG MAST-CELLS
    LAU, HYA
    WONG, PL
    LAI, CKW
    AGENTS AND ACTIONS, 1994, 42 (3-4): : 92 - 94