Steroidal Sapogenins and Glycosides from the Rhizomes of Dioscorea bulbifera

被引：44

作者：

Liu, Hai ^{[1
,2
,3
]}

Chou, Gui-Xin ^{[1
,2
]}

Wu, Tao ^{[1
,2
]}

Guo, Yin-Long ^{[3
]}

Wang, Shun-Chun ^{[1
,2
]}

Wang, Chang-Hong ^{[1
,2
]}

Wang, Zheng-Tao ^{[1
,2
]}

机构：

[1] Shanghai Univ Tradit Chinese Med, MOE Key Lab Standardizat Chinese Med, Inst Tradit Chinese Med, Shanghai 201210, Peoples R China

[2] Shanghai R&D Ctr Standardizat Chinese Med, Shanghai 201210, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai Mass Spectrometry Ctr, Shanghai 200032, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2009年 / 72卷 / 11期

基金：

中国国家自然科学基金;

关键词：

L. VAR SATIVA; CLERODANE DITERPENOIDS; BAFOUDIOSBULBIN-B; SAPONINS; CONSTITUENTS;

D O I：

10.1021/np900255h

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Four new steroidal sapogenins (1-4), named diosbulbisins A-D, two new spirostane glycosides, diosbulbisides A (5) and B (6), one new cholestane glycoside, diosbulbiside C (7), and the known compounds 8-10 were isolated from rhizomes of Dioscorea bulbifera. Their structures were elucidated by ID and 2D NMR techniques, HRFTMS, and chemical methods. The unusual furospirostanol sapogenin skeletons, as found in compounds 3 and 4, are reported in the family Dioscoreaceae for the first time. Cytotoxicity of compounds 1-10 was evaluated using two human hepatocellular carcinoma cell lines (Bel-7402 and SMMC7721).

引用

页码：1964 / 1968

页数：5

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